University of Maryland Medical Center, 110 South Paca Street 6(th) Floor Suite 300, Baltimore, MD 21201, United States.
The University of Maryland St. Joseph Medical Center, 7601 Osler Dr., Towson, MD 21204, United States.
Knee. 2021 Mar;29:426-431. doi: 10.1016/j.knee.2021.02.032. Epub 2021 Mar 13.
The optimal dosing of post-operative total knee arthroplasty (TKA) narcotics is unclear. We report on the average narcotic usage in a group of patients treated with an identical multimodal pain protocol following TKA.
49 patients undergoing TKA participated in the survey. Patients with pre-op narcotic use, recent prior total joint arthroplasty or study refusal were excluded. All patients received a spinal anesthetic. No pre-surgery narcotics were given. All received an identical local infiltrative anesthetic combination along with a multimodal pain protocol. Patients were placed into an identical rapid rehab program. Narcotic usage during hospitalization was recorded in morphine equivalent doses (MED). Patients were given a journal to record their daily narcotic utilization.
Pre-operative pain scores of the excluded groups had slightly higher but clinically insignificant differences compared to the study group. In the hospital, POD1 study group daily MED averaged 28 (range 0-110). POD2 had an average of 33.6 and POD 3 daily usages averaged 28.6 (range 0-100). By the end of week two, the average daily use was 19.2 and 24% patients were off all narcotics. By the end of week four, the average daily usage was 7.5 and 63% of patients were off all narcotics. By 8 weeks, there were no patients still taking narcotics. KSS averaged 76.9 (range 51-97) at the 6 week visit, and 94.2 at the 3-month visit (range 72-100).
This study documents the average needs of an average TKA patient treated with modern pain protocols. The majority of these patients were off narcotics by week four.
全膝关节置换术后(TKA)阿片类药物的最佳剂量尚不清楚。我们报告了一组接受相同多模式疼痛方案治疗的 TKA 患者的平均阿片类药物使用情况。
49 例接受 TKA 的患者参与了这项调查。排除术前使用阿片类药物、近期接受过全关节置换术或拒绝研究的患者。所有患者均接受了脊髓麻醉。术前未给予任何阿片类药物。所有患者均接受了相同的局部浸润性麻醉联合多模式疼痛方案。患者被纳入相同的快速康复计划。住院期间记录吗啡等效剂量(MED)的阿片类药物使用量。患者记录了他们的每日阿片类药物使用情况。
排除组的术前疼痛评分略高,但与研究组相比差异无统计学意义。在医院,第 1 天(POD1)研究组的平均每日 MED 为 28(范围 0-110)。第 2 天(POD2)平均为 33.6,第 3 天(POD3)平均为 28.6(范围 0-100)。在第 2 周结束时,平均每日使用量为 19.2,24%的患者停止使用所有阿片类药物。在第 4 周结束时,平均每日使用量为 7.5,63%的患者停止使用所有阿片类药物。第 8 周时,没有患者仍在服用阿片类药物。第 6 周时 KSS 平均为 76.9(范围 51-97),第 3 个月时为 94.2(范围 72-100)。
本研究记录了接受现代疼痛方案治疗的普通 TKA 患者的平均需求。大多数患者在第 4 周时已停止使用阿片类药物。