Department of Obstetrics and Gynecology, Key Laboratory of Birth Defects and Related Diseases of Women and Children of MOE, West China Second University Hospital.
Deep Underground Space Medical Center, West China Hospital, No. 37 Guoxuexiang.
Medicine (Baltimore). 2021 Mar 12;100(10):e25047. doi: 10.1097/MD.0000000000025047.
Nevus sebaceous (NS) is a lesion caused by congenital hyperplastic disorder of the sebaceous glands. It commonly noted in the scalp and face and rarely in the trunk, neck, or oral mucosa. We present a rare case of a lesion arising in the genital region.
A 47-year-old woman complained of a gradual increase in the size of her bilateral labia minora over 2 years, which affected her sexual life and caused walking difficulty. She was admitted to the Department of Obstetrics and Gynecology. On physical examination, no ulcer, discharge, and vulval or vaginal bleeding were found. The bilateral inguinal lymph nodes were not palpable, bilateral labia minora were asymmetric, and the right side was evidently bigger than the left. The labia minora had serrated edges and numerous papillae with a maximum diameter of 0.5 cm. The vagina, cervix, and uterus with its attachments were normal. Blood samples tested negative for human immunodeficiency virus, human papilloma virus, hepatitis B virus, and hepatitis C virus.
A diagnosis of NS of the bilateral labia minora was made following histopathological examination of the resected specimen.
The bilateral labia minora lesions were resected general anesthesia on August 29, 2016. The operation was successful, and intraoperative blood loss was about 10 ml.
After 40 months of postoperative follow-up, no recurrence or appearance of other tumors were noted.
We recommend surgical removal of lesions in the genital area during adolescence or before adulthood. Adolescence may be the best period for surgical intervention owing to a greater risk of malignant change in adulthood. On the other hand, surgical risk should be avoided in children considering the low incidence of malignant transformation.
皮脂腺痣（NS）是由皮脂腺先天性增生紊乱引起的病变。它常见于头皮和面部，很少见于躯干、颈部或口腔黏膜。我们报告了一例罕见的生殖器区域病变。
一名 47 岁女性，因双侧小阴唇逐渐增大 2 年，影响性生活和行走困难，于妇产科就诊。体格检查未见溃疡、分泌物、外阴或阴道出血。双侧腹股沟淋巴结未触及，双侧小阴唇不对称，右侧明显大于左侧。小阴唇边缘呈锯齿状，有多个乳头状突起，最大直径 0.5cm。阴道、宫颈和子宫及其附件正常。人免疫缺陷病毒、人乳头瘤病毒、乙型肝炎病毒和丙型肝炎病毒的血液样本检测均为阴性。
切除标本的组织病理学检查诊断为双侧小阴唇皮脂腺痣。
2016 年 8 月 29 日，在全身麻醉下行双侧小阴唇病变切除术。手术成功，术中出血量约 10ml。
术后随访 40 个月，未见复发或其他肿瘤出现。
我们建议在青春期或成年前切除生殖器区域的病变。由于成年后恶性转化的风险更高，青春期可能是手术干预的最佳时期。另一方面，考虑到恶性转化的发生率较低，应避免儿童的手术风险。
