Department of Medical Oncology.
Department of Pathology, Affiliated Dongyang Hospital of Wenzhou Medical University, Dongyang, Zhejiang, People's Republic of China.
Medicine (Baltimore). 2021 Mar 12;100(10):e25124. doi: 10.1097/MD.0000000000025124.
Although some studies have reported the expression and clinical significance of phosphorylated signal transducer and activator of transcription 3 (p-STAT3) in breast cancer tissues, it is still controversial whether p-STAT3 play a role in promoting or suppressing cancer. Here, we used immunohistochemistry analysis to explore expression of p-STAT3 in 407 cases of breast cancer, and analyzed the relationship between p-STAT3 expression and the clinicopathological characteristics and prognosis of breast cancer patients. Positive p-STAT3 expression was seen in 112 cases (27.5%) of breast cancer. p-STAT3 expression was negatively correlated with tumor size, tumor stage and human epidermal growth factor receptor 2 (HER2) status, and the positive rate of p-STAT3 was lowest in HER2-enriched subtype breast cancer (15.3%), while other subtypes were luminal B (23.0%), luminal A (30.2%), and triple-negative breast cancer (TNBC) (37.5%). Logistic regression model multivariate analysis showed that the independent correlation factor of p-STAT3 expression in breast cancer was tumor size (OR = 0.187, 95% CI = 0.042-0.839, P = .029) and HER2 status (OR = 0.392, 95% CI = 0.216-0.710, P = .002). In this study, no clear relationship was observed between patients' prognosis and expression of p-STAT3. Therefore, we suggest that p-STAT3 expression in breast cancer is negatively correlated with tumor size and HER2 status, but appears to have no effect on survival.
尽管一些研究已经报道了磷酸化信号转导和转录激活因子 3(p-STAT3)在乳腺癌组织中的表达及其临床意义，但 p-STAT3 是否在促进或抑制癌症中发挥作用仍存在争议。在这里，我们使用免疫组织化学分析方法研究了 407 例乳腺癌组织中 p-STAT3 的表达，并分析了 p-STAT3 表达与乳腺癌患者临床病理特征和预后的关系。在 407 例乳腺癌中，有 112 例(27.5%)的乳腺癌组织中存在 p-STAT3 的阳性表达。p-STAT3 的表达与肿瘤大小、肿瘤分期和人表皮生长因子受体 2(HER2)状态呈负相关，且在 HER2 富集型乳腺癌中 p-STAT3 的阳性率最低(15.3%)，而其他亚型为 luminal B(23.0%)、luminal A(30.2%)和三阴性乳腺癌(TNBC)(37.5%)。多因素 logistic 回归模型分析显示，乳腺癌中 p-STAT3 表达的独立相关因素是肿瘤大小(OR = 0.187，95%CI = 0.042-0.839，P = .029)和 HER2 状态(OR = 0.392，95%CI = 0.216-0.710，P = .002)。在本研究中，未观察到患者预后与 p-STAT3 表达之间存在明确的关系。因此，我们认为乳腺癌中 p-STAT3 的表达与肿瘤大小和 HER2 状态呈负相关，但似乎对生存没有影响。
