Department of Interventional Radiology, The First Affiliated Hospital of Zhengzhou University, Interventional Therapy Institute of Zhengzhou University, Zhengzhou, China.
Medicine (Baltimore). 2021 Mar 19;100(11):e25132. doi: 10.1097/MD.0000000000025132.
The aim of this study was to evaluate the effectiveness and safety of a partially covered metallic tracheal Y-shaped stent for the treatment of high cervical gastro-tracheal fistula (GTF) and tracheo-esophageal fistula (TEF). From January 2017 to January 2019, 16 patients with high cervical GTF and TEF received partially covered metallic Y-shaped stent placement under fluoroscopic guidance. The technical and clinical success rates, incidence of major complications, and survival outcomes were analyzed. Eastern Cooperative Oncology Group (ECOG) score and quality of life (SF-36 questionnaire) were compared pre and post stent placement. Technical and clinical success rates were 100% and 81.3%, respectively. Major complications (severe tumor ingrowth, mucostasis, hyperplastic granulation tissue) occurred in 7/16 (43.8%) patients. ECOG score and 5 of the 8 domains of the SF-36 (physical function, role physical, general health, vitality, social function) were significantly improved at 1 month after treatment (P < .01). During the median follow-up period of 8.3 months, 9 patients were alive. Median overall survival was 10.3 months (95% CI, 8.0-12.6). The newly designed partially covered tracheal Y-shaped stent appears to be effective and safe for treatment of high cervical GTF and TEF.
本研究旨在评估部分覆盖式金属气管 Y 型支架治疗高位颈段胃-气管瘘（GTF）和气管-食管瘘（TEF）的有效性和安全性。2017 年 1 月至 2019 年 1 月，16 例高位颈段 GTF 和 TEF 患者在透视引导下接受部分覆盖式金属 Y 型支架置入术。分析了技术和临床成功率、主要并发症发生率和生存结果。比较了支架置入前后东部肿瘤协作组（ECOG）评分和生活质量（SF-36 问卷）。技术和临床成功率分别为 100%和 81.3%。16 例患者中有 7 例（43.8%）发生严重肿瘤侵入、黏液阻塞、增生性肉芽组织等主要并发症。治疗后 1 个月 ECOG 评分和 SF-36 的 8 个领域中的 5 个（身体功能、身体角色、一般健康、活力、社会功能）均显著改善（P<.01）。在 8.3 个月的中位随访期间，9 例患者存活。中位总生存期为 10.3 个月（95%CI，8.0-12.6）。新型部分覆盖式气管 Y 型支架治疗高位颈段 GTF 和 TEF 有效且安全。
