Division of Population Health Sciences, Royal College of Surgeons in Ireland, Dublin, Ireland.
Health Service Executive, Research and Development, National Health Library & Knowledge Service, Dr. Steevens Hospital, Dublin 8, Ireland.
Eur J Radiol. 2021 May;138:109572. doi: 10.1016/j.ejrad.2021.109572. Epub 2021 Feb 11.
Interval breast cancers occur following a negative breast screening mammogram and before the next scheduled appointment within screening programmes. Radiological review classifies them as cancers that develop between screens, cancers with no obvious malignant abnormalities on prior screens or cancers not detected at screening. This study aimed to systematically review published literature on the occurrence of open disclosure following interval cancer radiological reviews by breast screening programmes internationally in a retrospective setting and examine methodologies used for radiological reviews for the purposes of disclosure.
A search for relevant articles published (January 2000 - May 2019) was conducted according to PICO and PRISMA guidelines. The databases Pubmed, Scopus, Google Scholar, Cinahl, Web of Science, Embase, Science Direct and Global Health were searched. Relevant studies were reviewed if they had completed a retrospective review and classification of interval breast cancers.
Of 46 relevant articles included, no study was identified that conducted a retrospective review purposely for open disclosure. Retrospective reviews were conducted for audit/quality assurance, and research including for radiologist education and learning. Variation in methodology was found across review type (non-blinded/semi-informed approach), number of reviewers and classification categories. The proportion of false negative cancers classified among the studies ranged from 4 to 40 %.
Variation among radiological review practices were observed, which likely impacts classification results. To ensure standardised classification of interval breast cancers are employed for the purposes of open disclosure in screening settings, reproducible and consistent methodology is required.
间隔期乳腺癌是在阴性乳腺筛查乳房 X 光照片之后和筛查计划中的下一次预定预约之前发生的。放射学复查将其分类为在筛查之间发展的癌症、在先前筛查中没有明显恶性异常的癌症或在筛查中未检测到的癌症。本研究旨在系统地回顾国际上乳腺筛查计划中回顾性间隔期癌症放射学复查后公开披露的已发表文献，并检查为披露目的而进行放射学复查所使用的方法。
根据 PICO 和 PRISMA 指南，对 2000 年 1 月至 2019 年 5 月发表的相关文章进行了搜索。检索了 Pubmed、Scopus、Google Scholar、Cinahl、Web of Science、Embase、Science Direct 和 Global Health 数据库。如果研究完成了回顾性复查和间隔期乳腺癌的分类，则对相关研究进行了回顾。
在 46 篇相关文章中，没有发现专门为公开披露而进行回顾性复查的研究。回顾性复查是为审计/质量保证、包括放射科医生教育和学习在内的研究而进行的。复查类型（非盲/半知情方法）、审查者人数和分类类别存在方法上的差异。研究中分类为假阴性癌症的比例从 4%到 40%不等。
观察到放射学复查实践存在差异，这可能影响分类结果。为了确保在筛查环境中为公开披露目的而采用标准化的间隔期乳腺癌分类，需要采用可重复和一致的方法。
