Bodnarenko S R, Rojas X, McKenna O C
Biopsychology Program, City University of New York, New York 10036.
J Comp Neurol. 1988 Mar 15;269(3):431-47. doi: 10.1002/cne.902690310.
Utilizing the horseradish peroxidase retrograde tracing technique and the 2-deoxy-D-glucose metabolic mapping technique, we have demonstrated in chickens the distribution of retinal ganglion cells that project to the lentiform nucleus of the mesencephalon (LM) and the retinotopic organization of the projection in the LM. Retinal ganglion cells labeled after a nearly complete injection into the LM were found in the four quadrants, distributed in a wide horizontal belt lying along both sides of the retinal equator and stretching from the temporal to the nasal retina. The HRP-labeled cells, which appeared round or oval, ranged from 25 to 840 micron 2 in size with most in the smaller size range. Results of partial HRP injections into the LM and metabolic mapping patterns in the LM produced by stimulation of half the retina with horizontal visual motion suggest that there is an orderly mapping of the retina onto the LM. The inferior temporal quadrant projects to the rostrodorsal LM; the inferior nasal quadrant projects to the caudodorsal LM. The superior temporal quadrant projects to the middle and ventral LM, extending from the rostral to the caudal pole, whereas the superior nasal quadrant projects to a small zone in the caudal LM. The mapping of the retinal quadrants in the LM is remarkably similar to that reported in the optic tectum of birds. We suggest that a common embryological anlage with the optic tectum and the arrangement of retinal axons in the optic tract are important factors in establishing the retinotopic organization of the LM.
利用辣根过氧化物酶逆行追踪技术和2-脱氧-D-葡萄糖代谢图谱技术，我们在鸡身上证明了投射到中脑豆状核（LM）的视网膜神经节细胞的分布以及该投射在LM中的视网膜拓扑组织。在几乎完全注入LM后标记的视网膜神经节细胞在四个象限中被发现，分布在沿着视网膜赤道两侧的宽水平带中，从颞侧视网膜延伸到鼻侧视网膜。HRP标记的细胞呈圆形或椭圆形，大小在25至840平方微米之间，大多数处于较小的尺寸范围内。将HRP部分注入LM的结果以及通过水平视觉运动刺激视网膜一半所产生的LM中的代谢图谱模式表明，视网膜在LM上存在有序的映射。颞下象限投射到LM的吻背侧；鼻下象限投射到LM的尾背侧。颞上象限投射到LM的中部和腹侧，从吻端延伸到尾端，而鼻上象限投射到LM尾侧的一个小区域。视网膜象限在LM中的映射与鸟类视顶盖中报道的映射非常相似。我们认为，与视顶盖共同的胚胎原基以及视束中视网膜轴突的排列是建立LM视网膜拓扑组织的重要因素。
