Division of Insurance Medicine, Department of Clinical Neuroscience, Karolinska Institutet, SE-171 77, Stockholm, Sweden.
Department of Molecular Medicine and Surgery, Karolinska Institutet, SE-171 77, Stockholm, Sweden.
J Cancer Surviv. 2022 Apr;16(2):269-278. doi: 10.1007/s11764-021-01017-7. Epub 2021 Mar 16.
To longitudinally investigate overall and diagnosis-specific sickness absence (SA) and disability pension (DP) in colorectal cancer (CRC) survivors and references and to identify potential risk factors.
This longitudinal register-based cohort study included all patients living in Sweden, diagnosed with a first primary CRC in 2008-2011 when aged 18-62 (n=6679), and their matched references (n=26 716). Net days of SA (in SA spells >14 days) and DP were analyzed from 2 years before through 5 years after diagnosis, overall and by specific diagnoses. Among survivors, risk factors for future SADP were explored using logistic regression.
In survivors, SA peaked in year 1 postdiagnosis, with 62.5% having at least some SA, and then gradually decreased to 20.1% in year 5. In the 2 years after diagnosis, CRC was the most common SA diagnosis in survivors, while SA due to mental diagnoses remained similar to the references. Notable risk factors for postdiagnostic SA or DP were rectal cancer diagnosis, advanced cancer stage at diagnosis, lower educational level, born outside of Sweden, and pre-diagnostic SA, mental morbidity, and comorbidities.
During 5 years after a CRC diagnosis, CRC survivors had higher levels of postdiagnostic SA and DP than the references, which was mostly due to CRC diagnoses. Although their SA lowered gradually, it did not return to pre-diagnostic levels.
Our results provide valuable information for patients with CRC diagnosis, especially that most have none or low levels of SA/DP after a few years.
纵向研究结直肠癌(CRC)幸存者和对照者的总体和特定诊断的病假(SA)和残疾抚恤金(DP),并确定潜在的风险因素。
本纵向基于登记的队列研究纳入了所有在 2008-2011 年年龄在 18-62 岁时诊断为首次原发性 CRC 的瑞典居民(n=6679)及其匹配对照者(n=26716)。从诊断前 2 年到诊断后 5 年,分析了 SA 天数(SA 发作中>14 天)和 DP,包括总体情况和特定诊断。在幸存者中,使用逻辑回归探索未来 SADP 的风险因素。
在幸存者中,SA 在诊断后 1 年达到高峰,有 62.5%至少有一些 SA,然后逐渐下降到诊断后 5 年的 20.1%。在诊断后 2 年,CRC 是幸存者中最常见的 SA 诊断,而由于精神诊断的 SA 则与对照者相似。诊断后 SA 或 DP 的显著风险因素包括直肠癌诊断、诊断时癌症分期较晚、较低的教育水平、出生在瑞典以外和诊断前 SA、精神疾病和合并症。
在 CRC 诊断后 5 年内,CRC 幸存者的诊断后 SA 和 DP 水平高于对照者,这主要是由于 CRC 诊断。尽管他们的 SA 逐渐降低,但仍未恢复到诊断前的水平。
我们的研究结果为 CRC 诊断患者提供了有价值的信息,特别是大多数患者在几年后没有或仅有少量的 SA/DP。