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[阅读障碍儿童的执行功能障碍]

[Executive functions disorders in children with dyslexia].

作者信息

Chutko L S, Surushkina S Yu, Yakovenko E A, I Anisimova T, Didur M D, Chekalova S A

机构信息

N. Bekhtereva Institute of Human Brain of the Russian Academy of Sciences, St. Petersburg, Russia.

Privolzhsky Research Medical University, Nizhniy Novgorod, Russia.

出版信息

Zh Nevrol Psikhiatr Im S S Korsakova. 2021;121(2):38-45. doi: 10.17116/jnevro202112102138.

Abstract

OBJECTIVE

To study the severity of disorders of executive functions in children with dyslexia and to assess the effectiveness of treatment of this pathology with cortexin.

MATERIAL AND METHODS

The main study group included 60 children, aged 8-11 years, with a specific reading disorder (F.81.0). Reading skills were assessed using methods of T.A. Fotekova, T.V. Akhutina. Diagnostic examination included neurological examination with dyspraxia test, electroencephalography with visual and quantitative analysis. To objectify the severity of memory impairments, the «Working memory» technique was used. Attention and impulsivity disorders were quantified using SNAP-IY and the Test of Variables of Attention (TOVA). The control group consisted of 60 children of the same age without symptoms of dyslexia. Cortexin was used to treat 30 patients from the study group, 30 patients received encephabol. A control study to analyze the effectiveness of the therapy was carried out one month after the end of therapy.

RESULTS AND CONCLUSION

Children with dyslexia are characterized by a higher level of inattention and impulsivity, as well as significantly lower indicators of working memory compared to children from the control group. The decrease in attention and working memory as well as an increased level of impulsivity are manifestations of impaired executive functions in children with dyslexia. The results of the control study after treatment showed a significant increase in reading skills in both groups. In addition, there was an improvement in indicators of attention and working memory. However, the effectiveness of treatment with cortexin was slightly higher compared to encephabol (improvement was noted in 73.3% and 60.0%of patients, respectively). According to a comparative analysis of EEG results, after a course of treatment with cortexin, children with dyslexia have significant neurophysiological changes that indicate the activation of the brain regulatory systems.

摘要

目的

研究诵读困难儿童执行功能障碍的严重程度,并评估皮质素治疗该病症的有效性。

材料与方法

主要研究组包括60名8至11岁患有特定阅读障碍(F.81.0)的儿童。阅读技能采用T.A. 福捷科娃、T.V. 阿胡蒂娜的方法进行评估。诊断检查包括伴有失用症测试的神经学检查、带有视觉和定量分析的脑电图检查。为客观评估记忆障碍的严重程度,采用了“工作记忆”技术。注意力和冲动障碍使用SNAP - IY和注意力变量测试(TOVA)进行量化。对照组由60名同龄且无诵读困难症状的儿童组成。研究组中的30名患者使用皮质素治疗,30名患者接受脑复康治疗。治疗结束一个月后进行对照研究以分析治疗效果。

结果与结论

与对照组儿童相比,诵读困难儿童的特点是注意力不集中和冲动水平较高,以及工作记忆指标显著较低。注意力和工作记忆的下降以及冲动水平的提高是诵读困难儿童执行功能受损的表现。治疗后的对照研究结果显示两组的阅读技能均有显著提高。此外,注意力和工作记忆指标也有所改善。然而,皮质素治疗的有效性略高于脑复康(分别有73.3%和60.0%的患者症状得到改善)。根据脑电图结果的对比分析,诵读困难儿童在接受皮质素疗程治疗后有显著的神经生理变化,表明大脑调节系统被激活。

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