Consultant Cardiologist, Kumaran Medical Center, Kurumbapalayam, Coimbatore, Tamil Nadu, 641107, India.
Associate Professor, Department of Cardiology, Kasturba Medical College, Manipal, Manipal Academy of Higher Education, Manipal, Karnataka, 576104, India.
Future Cardiol. 2021 Oct;17(7):1233-1239. doi: 10.2217/fca-2020-0163. Epub 2021 Mar 17.
The relationship between QT prolongation and myocardial ischemia is well known, however not many studies have correlated corrected QT interval and heart rate recovery with the severity of coronary artery disease (CAD). This was a single-center, prospective, observational study which included 127 patients with CAD and 124 patients without CAD. Corrected QT variability from peak to recovery correlated well with CAD with a p value of 0.03. Receiver operative characteristic analysis did not show any significant diagnostic accuracy with any heart rate or QT parameters for predicting the presence or severity of CAD. Coronary artery disease is predicted by reduced ability of the heart rate to rise from rest to peak exercise and reduced recovery of heart rate and corrected QT from peak exercise to recovery at 1 min.
QT 延长与心肌缺血的关系众所周知，但很少有研究将校正 QT 间期和心率恢复与冠状动脉疾病（CAD）的严重程度相关联。这是一项单中心、前瞻性、观察性研究，共纳入 127 例 CAD 患者和 124 例非 CAD 患者。从峰值到恢复的校正 QT 变异性与 CAD 相关性良好，p 值为 0.03。受试者工作特征分析显示，任何心率或 QT 参数均不能准确预测 CAD 的存在或严重程度。CAD 可通过静息至峰值运动时心率升高能力下降以及峰值运动至 1 分钟时心率和校正 QT 恢复能力下降来预测。
