供体谷氨酰转移酶与肝移植排斥和失败有关。
Donor Gamma-Glutamyl Transferase Is Associated With Liver Allograft Discard and Failure.
机构信息
School of Medicine, 3989Baylor College of Medicine, Houston, TX, USA.
Division of Abdominal Transplantation, Michael E DeBakey, Department of General Surgery, 3989Baylor College of Medicine, Houston, TX, USA.
出版信息
Prog Transplant. 2021 Jun;31(2):101-107. doi: 10.1177/15269248211002800. Epub 2021 Mar 17.
INTRODUCTION
The disparity between the number of individuals on the wait list and available liver allografts creates the need for a system that maximizes donor liver utilization and predicts graft failure.
RESEARCH QUESTION
This study aimed to determine the relationship between donor Gamma-Glutamyl Transferase (GGT), liver discard, and graft failure.
DESIGN
Through multivariate analysis from 53 966 deceased liver donors, we adjusted for donor clinical and demographic characteristics and compared donor GGT with allograft discard. We compared donor GGT ranges with graft failure and analyzed data from 47 269 liver recipients.
RESULTS
After adjusting for other factors, donor GGT was significantly associated with liver discard, with GGT over 200 U/L being most significant (OR 2.74, CI 2.51-2.99). Donor GGT under 20 U/L was also found to be a protective factor for post-transplant graft failure (HR 0.91, CI 0.83 - 1.00).
CONCLUSION
Going forward, GGT should be included among other characteristics associated with allograft discard considered during the procurement process.
简介
等待名单上的人数与可用肝供体之间的差距，使得我们需要建立一个系统，以最大化供体肝脏的利用率并预测移植物衰竭。
研究问题
本研究旨在确定供体γ-谷氨酰转移酶（GGT）、肝脏废弃与移植物衰竭之间的关系。
设计
通过对 53966 例已故肝供体的多变量分析，我们调整了供体的临床和人口统计学特征，并比较了供体 GGT 与同种异体肝废弃的关系。我们比较了供体 GGT 范围与移植物衰竭的关系，并分析了 47269 例肝移植受者的数据。
结果
在调整了其他因素后，供体 GGT 与肝废弃显著相关，其中 GGT 超过 200U/L 最为显著（OR 2.74，CI 2.51-2.99）。我们还发现，供体 GGT 低于 20U/L 是移植后移植物衰竭的保护因素（HR 0.91，CI 0.83-1.00）。
结论
在未来，GGT 应与其他与同种异体肝废弃相关的特征一起，纳入到获取过程中考虑的因素中。
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