Gaspar Pâmela Cristina, Bigolin Álisson, Alonso Neto José Boullosa, Pereira Esdras Daniel Dos Santos, Bazzo Maria Luiza
Ministério da Saúde, Secretaria de Vigilância em Saúde, Brasília, DF, Brasil.
Universidade Federal de Santa Catarina, Programa de Pós-Graduação em Farmácia, Florianópolis, SC, Brasil.
Epidemiol Serv Saude. 2021 Mar 15;30(spe1):e2020630. doi: 10.1590/S1679-4974202100006.esp1. eCollection 2021.
The recommendations for diagnostic tests for investigating syphilis are part of the Clinical Protocol and Therapeutic Guidelines for Comprehensive Care for People with Sexually Transmitted Infections and the Technical Manual for Syphilis Diagnosis, published by the Brazilian Ministry of Health. These recommendations were developed based on scientific evidence and discussions with a panel of experts. Aiming to contribute to the efforts of health service managers and health professionals in qualifying health care, this article presents the use of direct tests to detect Treponema pallidum in lesions, as well as algorithms that combine treponemal and non-treponemal antibody tests to assist in the diagnosis of syphilis. The article also covers use of non-treponemal tests to investigate neurosyphilis and guidelines for interpreting non-treponemal antibody titers in monitoring treatment and diagnosis of congenital syphilis, as well as prospects for innovations in diagnosis. The important role of rapid immunochromatographic treponemal tests for public health and for addressing syphilis is also highlighted.
梅毒调查诊断测试的建议是巴西卫生部发布的《性传播感染患者综合护理临床协议与治疗指南》以及《梅毒诊断技术手册》的一部分。这些建议是基于科学证据并与专家小组讨论后制定的。为了助力卫生服务管理人员和卫生专业人员提升医疗服务质量，本文介绍了用于检测病变部位梅毒螺旋体的直接检测方法，以及结合梅毒螺旋体和非梅毒螺旋体抗体检测以辅助梅毒诊断的算法。本文还涵盖了用于神经梅毒调查的非梅毒螺旋体检测，以及在监测先天性梅毒治疗和诊断中解释非梅毒螺旋体抗体滴度的指南，还有诊断创新的前景。文中还强调了快速免疫层析梅毒螺旋体检测在公共卫生和应对梅毒方面的重要作用。
