在糖尿病合并艾滋病病毒感染者中，比克替拉韦与二甲双胍之间不存在具有临床意义的相互作用。 - Suppr

Lack of clinically relevant interactions between bictegravir and metformin in persons with diabetes and HIV.

作者信息

Cattaneo Dario, Formenti Tiziana, Minisci Davide, Casalini Giacomo, Meraviglia Paola, Gervasoni Cristina

机构信息

Unit of Clinical Pharmacology, Fatebenefratelli Sacco University Hospital, Milan, Italy.

Gestione Ambulatoriale Politerapie (GAP) outpatient clinic, ASST Fatebenefratelli Sacco University Hospital, Milan, Italy.

出版信息

J Antimicrob Chemother. 2021 Jun 18;76(7):1945-1946. doi: 10.1093/jac/dkab077.

DOI:10.1093/jac/dkab077

PMID:33729482

Abstract

摘要

相似文献

Lack of clinically relevant interactions between bictegravir and metformin in persons with diabetes and HIV.在糖尿病合并艾滋病病毒感染者中，比克替拉韦与二甲双胍之间不存在具有临床意义的相互作用。

J Antimicrob Chemother. 2021 Jun 18;76(7):1945-1946. doi: 10.1093/jac/dkab077.

Coformulated bictegravir, emtricitabine, and tenofovir alafenamide versus dolutegravir with emtricitabine and tenofovir alafenamide, for initial treatment of HIV-1 infection (GS-US-380-1490): a randomised, double-blind, multicentre, phase 3, non-inferiority trial.比克替拉韦、恩曲他滨与丙酚替诺福韦二吡呋酯复方片剂与多替拉韦加拉米夫定和丙酚替诺福韦二吡呋酯用于治疗人类免疫缺陷病毒 1 型感染的初始治疗（GS-US-380-1490）：一项随机、双盲、多中心、3 期、非劣效性试验。

Lancet. 2017 Nov 4;390(10107):2073-2082. doi: 10.1016/S0140-6736(17)32340-1. Epub 2017 Aug 31.

Bictegravir versus dolutegravir, each with emtricitabine and tenofovir alafenamide, for initial treatment of HIV-1 infection: a randomised, double-blind, phase 2 trial.比克替拉韦与多替拉韦、恩曲他滨和丙酚替诺福韦二吡呋酯用于 HIV-1 感染初始治疗的双盲、随机、2 期临床试验

Lancet HIV. 2017 Apr;4(4):e154-e160. doi: 10.1016/S2352-3018(17)30016-4. Epub 2017 Feb 15.

Fixed-dose combination bictegravir, emtricitabine, and tenofovir alafenamide versus dolutegravir-containing regimens for initial treatment of HIV-1 infection: week 144 results from two randomised, double-blind, multicentre, phase 3, non-inferiority trials.固定剂量复方比克替拉韦、恩曲他滨和丙酚替诺福韦艾拉酚胺与含多替拉韦方案治疗初治人类免疫缺陷病毒 1 型感染：两项随机、双盲、多中心、Ⅲ期、非劣效性临床试验的 144 周结果。

Lancet HIV. 2020 Jun;7(6):e389-e400. doi: 10.1016/S2352-3018(20)30099-0.

Efficacy and safety of switching to fixed-dose bictegravir, emtricitabine, and tenofovir alafenamide from boosted protease inhibitor-based regimens in virologically suppressed adults with HIV-1: 48 week results of a randomised, open-label, multicentre, phase 3, non-inferiority trial.在病毒学抑制的 HIV-1 成人中，从基于增效蛋白酶抑制剂的方案转换为固定剂量比克替拉韦、恩曲他滨和替诺福韦艾拉酚胺的疗效和安全性：一项随机、开放标签、多中心、3 期、非劣效性试验的 48 周结果。

Lancet HIV. 2018 Jul;5(7):e347-e356. doi: 10.1016/S2352-3018(18)30091-2. Epub 2018 Jun 18.

Switching to fixed-dose bictegravir, emtricitabine, and tenofovir alafenamide from dolutegravir plus abacavir and lamivudine in virologically suppressed adults with HIV-1: 48 week results of a randomised, double-blind, multicentre, active-controlled, phase 3, non-inferiority trial.从多替拉韦加阿巴卡韦和拉米夫定转换为固定剂量比克替拉韦、恩曲他滨和替诺福韦艾拉酚胺治疗病毒学抑制的 HIV-1 成人患者：一项随机、双盲、多中心、活性对照、3 期、非劣效性临床试验的 48 周结果。

Lancet HIV. 2018 Jul;5(7):e357-e365. doi: 10.1016/S2352-3018(18)30092-4. Epub 2018 Jun 18.

Co-formulated bictegravir, emtricitabine, and tenofovir alafenamide versus dolutegravir with emtricitabine and tenofovir alafenamide for initial treatment of HIV-1 infection: week 96 results from a randomised, double-blind, multicentre, phase 3, non-inferiority trial.比克替拉韦、恩曲他滨与丙酚替诺福韦二吡呋酯固定剂量复方片与多替拉韦加拉米夫定用于治疗人类免疫缺陷病毒 1 型感染的初治：96 周随机、双盲、多中心、3 期、非劣效性试验结果。

Lancet HIV. 2019 Jun;6(6):e364-e372. doi: 10.1016/S2352-3018(19)30080-3. Epub 2019 May 5.

Failure to bictegravir and development of resistance mutations in an antiretroviral-experienced patient.在一名有抗逆转录病毒治疗经验的患者中，未能使用比克替拉韦且出现耐药突变。

Antiviral Res. 2020 Jul;179:104717. doi: 10.1016/j.antiviral.2020.104717. Epub 2020 Jan 23.

The potential role of bictegravir/emtricitabine/tenofovir alafenamide (BIC/FTC/TAF) single-tablet regimen in the expanding spectrum of fixed-dose combination therapy for HIV.比克替拉韦/恩曲他滨/丙酚替诺福韦（BIC/FTC/TAF）单片制剂方案在不断扩大的 HIV 固定剂量复方治疗谱中的潜在作用。

HIV Med. 2020 Mar;21 Suppl 1:3-16. doi: 10.1111/hiv.12833.

Crushed bictegravir/emtricitabine/tenofovir alafenamide in a human immunodeficiency virus-positive patient with esophageal cancer.一名患有食管癌的人类免疫缺陷病毒阳性患者中碾碎的比克替拉韦/恩曲他滨/替诺福韦艾拉酚胺

Am J Health Syst Pharm. 2020 Mar 24;77(7):509-510. doi: 10.1093/ajhp/zxaa017.

引用本文的文献

Polypharmacy and Aging in People Living with HIV: 6 Years of Experience in a Multidisciplinary Outpatient Clinic.多药治疗与 HIV 感染者老龄化：多学科门诊 6 年经验。

Drugs Aging. 2023 Jul;40(7):665-674. doi: 10.1007/s40266-023-01037-1. Epub 2023 Jun 13.

Bictegravir and Metformin Drug-Drug Interaction in People with Human Immunodeficiency Virus (HIV).比克替拉韦与二甲双胍在人类免疫缺陷病毒（HIV）感染者中的药物相互作用

Infect Dis Rep. 2023 Apr 25;15(3):231-237. doi: 10.3390/idr15030024.

Drug-drug interactions of Integrase Strand Transfer Inhibitors among older people living with HIV: Interazioni farmacologiche degli inibitori delle integrase tra le persone anziane che vivono con HIV.老年HIV感染者中整合酶链转移抑制剂的药物相互作用：老年HIV感染者中整合酶抑制剂的药物相互作用

J HIV Ageing. 2022 Jun;7(2):29-36. doi: 10.19198/jha31533.

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