Stoddart R C, Crompton D W
Department of Zoology, University of Glasgow, Scotland.
J Helminthol. 1988 Mar;62(1):91-4. doi: 10.1017/s0022149x00011275.
A technique is described whereby young adult Moniliformis moniliformis, aged up to 7 days, can be transferred via the oral route from one rat to another. The method is dependent on giving the recipient rats a dose of Cimetidine (0.25 ml/250 g body weight of a solution containing 950 mg/ml) 1 h before transfer. Cimetidine functions as an H2-receptor antagonist and gastric acid secretion in the rat is inhibited temporarily. The technique does not appear to interfere with the reproductive biology of the parasite.
本文描述了一种技术,通过该技术可将7日龄以内的成年念珠棘虫经口从一只大鼠转移至另一只大鼠。该方法的关键在于在转移前1小时给受体大鼠注射西咪替丁(每250克体重注射0.25毫升,溶液浓度为950毫克/毫升)。西咪替丁作为一种H2受体拮抗剂,可暂时抑制大鼠胃酸分泌。该技术似乎不会干扰寄生虫的生殖生物学特性。