Jünemann Anselm G M, Grieb P, Rejdak R
Department of General and Pediatric Ophthalmology Service, Medical University of Lublin, Chmielna 1 str., 20-079, Lublin, Polen.
Department of Experimental Pharmacology, Mossakowski Medical Research Centre, Polish Academy of Sciences, Warschau, Polen.
Ophthalmologe. 2021 May;118(5):439-448. doi: 10.1007/s00347-021-01362-z. Epub 2021 Mar 17.
In recent years, many experimental and clinical studies have shown that in glaucoma, neuronal degeneration occurs not only at the level of the retina and optic nerve, but also along the entire visual pathway and the brain.
This article presents the neuroprotective effects of citicoline and their mechanisms in glaucoma disease.
The relevance of citicoline is explained against the background of neuroanatomy, neuroimaging, and the pathogenesis of glaucoma. Data from experimental and clinical studies are presented and a conclusion is drawn for clinical application.
Citicoline has a neuroprotective effect via mechanisms relevant to glaucoma. The neuroprotective effect of citicoline in open-angle glaucoma can be demonstrated functionally and morphologically. It is independent of the glaucoma damage and intraocular pressure, and usually occurs only after 1 year. The effects of oral citicoline occur at a daily dose of 500-1000 mg. Citicoline can be taken permanently or in cycles. No side effects occurred in the studies when taking citicoline. Citicoline can improve cognitive performance and thus treatment adherence as well as quality of life in glaucoma patients.
This relatively old nootropic drug, which is now marketed as a food supplement, seems to be a valuable addition to conventional treatment and also a rational option for prophylaxis of open-angle glaucoma.
近年来，许多实验和临床研究表明，在青光眼患者中，神经元变性不仅发生在视网膜和视神经水平，还发生在整个视觉通路及大脑。
本文介绍了胞磷胆碱在青光眼疾病中的神经保护作用及其机制。
在神经解剖学、神经影像学及青光眼发病机制的背景下解释胞磷胆碱的相关性。展示了实验和临床研究的数据，并得出临床应用结论。
胞磷胆碱通过与青光眼相关的机制发挥神经保护作用。胞磷胆碱在开角型青光眼中的神经保护作用可通过功能和形态学得到证实。它独立于青光眼损害和眼压，通常仅在1年后出现。口服胞磷胆碱的效果在每日剂量500 - 1000毫克时出现。胞磷胆碱可以长期服用或循环服用。在服用胞磷胆碱的研究中未出现副作用。胞磷胆碱可以改善认知能力，从而提高青光眼患者的治疗依从性及生活质量。
这种相对古老的促智药，现作为食品补充剂销售，似乎是传统治疗的宝贵补充，也是预防开角型青光眼的合理选择。
