Department of Midwifery and Reproductive Health, School of Nursing and Midwifery, Tehran University of Medical Sciences, Tehran, Iran.
Social Determinants of Health Research Center, Tabriz University of Medical Sciences, Tabriz, Iran,
Complement Med Res. 2021;28(5):419-426. doi: 10.1159/000514944. Epub 2021 Mar 17.
Menopause and estrogen deprivation cause a rise in the number of urogenital tract complaints.
This study was conducted to assess the effectiveness of ginseng on genitourinary syndrome.
This randomized trial was conducted on 60 postmenopausal women with genitourinary syndrome. The participants were randomly allocated to ginseng and placebo groups twice daily for 4 weeks. Vaginal maturation index and vaginal pH were evaluated before and 4 weeks after intervention as the primary outcomes. Also, the atrophic vaginitis and incontinence questionnaires were completed before and after intervention as the secondary outcomes. The safety of intervention was assessed by the side effects checklist.
No significant differences were observed between the 2 groups in objective symptoms after the intervention, but the difference was statistically significant (p < 0.001) in terms of subjective symptoms of atrophic vaginitis. One case of insomnia and palpitation and 2 cases of hot flashes were reported in the intervention group, and 1 case of gastric discomfort and change in urine appearance was reported in the placebo group.
Ginseng only improved the patient-assessed symptoms and had no significant effect on the clinician-assessed outcomes. Further studies are required to determine the precise pharmacological mechanisms of ginseng on genitourinary syndrome.
绝经和雌激素缺乏会导致泌尿生殖道问题的增加。
本研究旨在评估人参对女性泌尿生殖系统综合征的疗效。
这是一项随机试验，共纳入 60 例患有泌尿生殖系统综合征的绝经后妇女。参与者被随机分为人参组和安慰剂组，每天两次，持续 4 周。干预前后评估阴道成熟指数和阴道 pH 值作为主要结局，干预前后还完成萎缩性阴道炎和尿失禁问卷作为次要结局。通过副作用清单评估干预的安全性。
干预后，两组在客观症状方面无显著差异，但在萎缩性阴道炎的主观症状方面差异有统计学意义（p<0.001）。人参组有 1 例失眠和心悸，2 例潮热，安慰剂组有 1 例胃部不适和尿液外观改变。
人参仅改善了患者评估的症状，对临床医生评估的结果没有显著影响。需要进一步研究确定人参对女性泌尿生殖系统综合征的确切药理机制。
