Department of Rehabilitation Sciences, Jordan University of Science & Technology, Faculty of Applied Medical Sciences, Irbid, Jordan.
School of Medicine, Department of Physical Therapy & Rehabilitation Science, University of Maryland, Baltimore, Baltimore, Maryland.
Neurodegener Dis Manag. 2021 Apr;11(2):113-124. doi: 10.2217/nmt-2020-0053. Epub 2021 Mar 18.
Pain and fatigue are highly prevalent debilitating symptoms in Parkinson's disease (PD), however, their relationship with physical performance, fear of falling (FOF) and falls is not clear. We aim in this pilot study to investigate the relationship of pain and fatigue with physical performance, FOF and falls in people with Parkinson's disease (PwPD). 53 PD patients were assessed for fall history, physical performance, FOF, pain and fatigue. Pain and fatigue are significantly associated with physical performance and FOF (p ≤ 0.002). Pain and fatigue were different between fallers and non-fallers (p < 0.5), but only fatigue could distinguish fallers from non-fallers (area under the receiver operating characteristics curve = 0.81; p < 0.0001). This pilot study indicated that FOF in PwPD is significantly associated with pain and fatigue. Furthermore, fatigue level is related to fall history. By addressing pain and fatigue, we may ameliorate the deterioration of FOF and falls in PwPD.
疼痛和疲劳是帕金森病（PD）中非常普遍且使人虚弱的症状，但它们与身体机能、跌倒恐惧（FOF）和跌倒之间的关系尚不清楚。本研究旨在初步探讨帕金森病患者的疼痛和疲劳与身体机能、跌倒恐惧和跌倒之间的关系。 对 53 名 PD 患者进行了跌倒史、身体机能、跌倒恐惧、疼痛和疲劳评估。 疼痛和疲劳与身体机能和跌倒恐惧显著相关（p ≤ 0.002）。跌倒者与非跌倒者之间的疼痛和疲劳存在差异（p < 0.5），但只有疲劳可以区分跌倒者和非跌倒者（受试者工作特征曲线下面积 = 0.81；p < 0.0001）。 本初步研究表明，帕金森病患者的跌倒恐惧与疼痛和疲劳显著相关。此外，疲劳水平与跌倒史相关。通过解决疼痛和疲劳问题，我们可能会改善帕金森病患者跌倒恐惧和跌倒的恶化。
