Neonatal Netw. 2021 Mar 1;40(2):66-72. doi: 10.1891/0730-0832/11-T-675.
To describe early neurodevelopment outcomes of neonates with severe hyperbilirubinemia without acute bilirubin encephalopathy (ABE).
Neonates born at gestation ≥35 weeks, admitted to NICU with total serum bilirubin (TSB) in exchange range with no features of ABE, were followed up until the age of 6 months. Infants were assessed for impaired hearing and neurodevelopment at 3 months and 6 months of age.
A total of 59 neonates were enrolled in the study. At 3 months of age, 7.6 percent of neonates were found to have hypotonia and motor delay, whereas 42.3 percent had abnormal brainstem evoked response audiometery. At 6 months, 6.4 percent of neonates were found to have persistent neurodevelopmental impairment.
Severe hyperbilirubinemia is associated with impaired neurodevelopment and hearing even in infants without ABE. Peak TSB level strongly correlates with abnormal outcomes.
描述无急性胆红素脑病（ABE）的重度高胆红素血症新生儿的早期神经发育结局。
对胎龄≥35 周、因总胆红素（TSB）处于换血范围且无 ABE 特征而入住 NICU 的新生儿进行随访，直至 6 个月龄。在 3 个月和 6 个月龄时评估婴儿的听力和神经发育受损情况。
本研究共纳入 59 例新生儿。3 个月龄时，7.6%的新生儿存在张力低下和运动延迟，而 42.3%的新生儿脑干听觉诱发电位异常。6 个月龄时，6.4%的新生儿存在持续的神经发育障碍。
即使在无 ABE 的婴儿中，重度高胆红素血症也与神经发育和听力受损有关。峰值 TSB 水平与异常结局密切相关。
