John A. Paulson School of Engineering and Applied Sciences and Wyss Institute for Biologically Inspired Engineering, Harvard University, Cambridge, MA 02138, USA.
Joslin-Beth Israel Deaconess Foot Center and The Rongxiang Xu, MD, Center for Regenerative Therapeutics, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02115, USA.
Sci Transl Med. 2021 Mar 17;13(585). doi: 10.1126/scitranslmed.abe4839.
Current treatment options for foot ulcers, a serious and prevalent complication of diabetes, remain nonspecific. In this Perspective, we present recent advances in understanding the pathophysiology of diabetic wound healing and the emergence of previously unidentified targets. We discuss wound dressings tailored to the diabetic wound environment currently under development.
目前针对足部溃疡(糖尿病的一种严重且普遍的并发症)的治疗方法仍然是非特异性的。在本观点中,我们介绍了在理解糖尿病伤口愈合的病理生理学和以前未被发现的目标方面的最新进展。我们讨论了目前正在开发的针对糖尿病伤口环境的伤口敷料。