沙特无症状人群中的因子 XII 缺乏症：一项回顾性队列研究。
Factor XII deficiency in asymptomatic Saudi population: A retrospective cohort study.
作者信息
Alqahtany Fatmah S, Algahtani Farjah H, Alshebly Mashael M, Albegamy Thamer S, Alghamdi Essam S, Alnakhli Mohammed A, Madkhaly Fatimah M, Alharbi Abdullah A, Alqahtani Nawaf A
机构信息
Department of Pathology, Hematopathology Unit, College of Medicine, King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia.
Department of Medicine, Division of Oncology/Hematology, College of Medicine, King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia.
出版信息
Saudi J Biol Sci. 2021 Mar;28(3):2004-2006. doi: 10.1016/j.sjbs.2021.01.002. Epub 2021 Jan 8.
Factor XII (FXII) deficiency is a rare genetic blood disorder. It can lead to a higher risk of developing deep vein thrombosis or acquired thrombotic disorders than the general population. This retrospective study evaluated patients who opted for surgery and were found to have abnormal clotting profiles and clotting factors on preoperative routine blood. Patients were included regardless of whether they were symptomatic or asymptomatic. The cohort comprised 115 patients with a mean FXII level of 128.04 ± 36.93%. Two (1.79%) patients, both of whom were women, had FXII levels <60%. The mean FXII level was 58 ± 1.41 (range, 57-59%) in this group. The present study shows the prevalence of FXII in the asymptomatic Saudi population. The results provide the normal range for FXII. The findings of our study provide the basis for diagnosing deficiency in the asymptomatic Saudi population.
凝血因子 XII（FXII）缺乏症是一种罕见的遗传性血液疾病。与普通人群相比，它会导致发生深静脉血栓形成或获得性血栓形成疾病的风险更高。这项回顾性研究评估了选择手术且术前常规血液检查发现凝血指标和凝血因子异常的患者。无论患者有无症状均被纳入研究。该队列包括115名患者，平均FXII水平为128.04±36.93%。两名（1.79%）患者FXII水平<60%，且均为女性。该组患者的平均FXII水平为58±1.41（范围为57 - 59%）。本研究显示了无症状沙特人群中FXII的患病率。研究结果提供了FXII的正常范围。我们的研究结果为诊断无症状沙特人群中的FXII缺乏症提供了依据。
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