Chong-Morrison Vanessa, Sauka-Spengler Tatjana
Radcliffe Department of Medicine, Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, United Kingdom.
Front Physiol. 2021 Mar 1;12:634440. doi: 10.3389/fphys.2021.634440. eCollection 2021.
Neural crest ontogeny plays a prominent role in craniofacial development. In this Perspective article, we discuss recent advances to the understanding of mechanisms underlying the cranial neural crest gene regulatory network (cNC-GRN) stemming from -based studies. We briefly summarize how parallel considerations of transcriptome, interactome, and epigenome data significantly elaborated the roles of key players derived from pre- era studies. Furthermore, the growing cohort of cNC multiomics data revealed contribution of the non-coding genomic landscape. As technological improvements are constantly being developed, we reflect on key questions we are poised to address by taking advantage of the unique perspective a multiomics approach has to offer.
神经嵴个体发生在颅面发育中起着重要作用。在这篇观点文章中，我们讨论了基于[具体技术]研究对理解颅神经嵴基因调控网络（cNC-GRN）潜在机制的最新进展。我们简要总结了转录组、相互作用组和表观基因组数据的平行考量如何显著阐述了源自[之前时代]研究的关键参与者的作用。此外，越来越多的cNC多组学数据揭示了非编码基因组格局的贡献。随着技术不断改进，我们思考利用多组学方法所提供的独特视角准备解决的关键问题。
