Brown P H, Juni J E, Lieberman D A, Krishnamurthy G T
Division of Gastroenterology, VA Medical Center, Portland, OR 97207.
J Nucl Med. 1988 May;29(5):623-30.
A combination of quantitative hepatobiliary imaging techniques was developed to study normal control subjects and patients with 3 categories of hepatobiliary disease: 1) alcoholic cirrhosis; 2) sclerosing cholangitis; and 3) isolated common bile duct obstruction. Scintigraphic images were supplemented by quantitative measurement of hepatic extraction fraction by deconvolutional analysis and liver excretion T 1/2 by a nonlinear least squares method. In diseases confined primarily to the biliary tract (isolated common bile duct obstruction and sclerosing cholangitis), the mean hepatic extraction fraction as measured by deconvolutional analysis was not different from that in normal controls. In severe alcoholic cirrhosis, considered primarily a hepatocyte disease, the hepatic extraction fraction was markedly reduced. The T 1/2 excretion, compared to normal subjects, was prolonged in all three liver disease categories. We conclude that these quantitative parameters were able to detect hepatobiliary disease and to separate severe hepatocyte disease from biliary tract disease.
开发了一种定量肝胆成像技术的组合，用于研究正常对照受试者和患有三类肝胆疾病的患者：1）酒精性肝硬化；2）硬化性胆管炎；3）孤立性胆总管梗阻。通过去卷积分析对肝脏提取分数进行定量测量，并通过非线性最小二乘法对肝脏排泄半衰期进行测量，以此补充闪烁图像。在主要局限于胆道的疾病（孤立性胆总管梗阻和硬化性胆管炎）中，通过去卷积分析测量的平均肝脏提取分数与正常对照组无异。在主要被视为肝细胞疾病的严重酒精性肝硬化中，肝脏提取分数显著降低。与正常受试者相比，所有三类肝病的排泄半衰期均延长。我们得出结论，这些定量参数能够检测肝胆疾病，并将严重的肝细胞疾病与胆道疾病区分开来。
