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墨西哥西部一家三级医疗机构尿路感染的微生物学分析:最新进展。

Microbiological profile of urinary tract infections in a tertiary medical facility in Western Mexico: An update.

机构信息

Department of Urology, Western National Medical Center Instituto Mexicano del Seguro Social (IMSS), Guadalajara, Jalisco, Mexico.

Microbiology and Parasitology Department, University of Guadalajara (CUCS), Guadalajara, Jalisco, México.

出版信息

Sci Prog. 2021 Jan-Mar;104(1):368504211000886. doi: 10.1177/00368504211000886.

Abstract

Urinary tract infections (UTIs) are one of the most important issues in modern medicine. In developing countries, the use of antibiotics is a common practice, and due to this, antibiotic resistance has increased. The objective of this research was to update and report on the microbiological profile of urinary tract infections based on the number of positive urine cultures (UCs), resistance, sensitivity, and the prevalence of bacterial strains. The results were obtained from the database of a tertiary medical facility in Western Mexico. The number of positive UCs was 1769 from inpatients and outpatients who were users of medical services in the hospital from January to December of 2017. The most commonly isolated microorganism was , with 1225 cases, of which 603 (49.2%) were ESBL (Extended-Spectrum Beta-Lactamase-producing bacteria) strains. The resistance rate of nitrofurantoin was 36.6%, and meropenem showed the most promising results with a resistance rate of only 7.1%. Resistances to quinolones and cephalosporins among the isolates investigated were 51%-67%. Based on our results, it is necessary to increase controls and to improve management protocols in order to achieve better medical practices by reducing antibiotic resistance.

摘要

尿路感染(UTIs)是现代医学中最重要的问题之一。在发展中国家,抗生素的使用是一种常见的做法,因此,抗生素耐药性有所增加。本研究的目的是根据阳性尿液培养物(UCs)的数量、耐药性、敏感性以及细菌菌株的流行情况,更新和报告尿路感染的微生物学特征。结果来自于 2017 年 1 月至 12 月期间,墨西哥西部一家三级医疗机构的数据库。阳性 UCs 的数量为 1769 例,来自住院和门诊患者,他们是医院医疗服务的使用者。最常分离的微生物是 ,有 1225 例,其中 603 例(49.2%)为产超广谱β-内酰胺酶(ESBL)的细菌株。呋喃妥因的耐药率为 36.6%,而美罗培南的耐药率仅为 7.1%,显示出最有希望的结果。所研究的分离株对喹诺酮类和头孢菌素的耐药率为 51%-67%。根据我们的结果,有必要加强控制并改进管理方案,以减少抗生素耐药性,从而实现更好的医疗实践。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9340/10358542/7bd742797736/10.1177_00368504211000886-fig1.jpg

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