Ann Romney Center for Neurologic Diseases, Brigham and Women's Hospital, Boston, MA, USA.
Department of Neurology, Harvard Medical School, Boston, MA, USA.
Acta Neurol Scand. 2021 Jul;144(1):13-20. doi: 10.1111/ane.13415. Epub 2021 Mar 18.
Neurofilament light chain (NfL) is an incredibly specific marker of neuronal injury that is not specific for cause or location of the neuronal damage. NfL is increasingly considered as possible biomarker of disease activity in neurological conditions. Several works reviewed the utility of NfL in the different diseases. Nonetheless, NfL is a universal marker of neuronal damage, which interpretation spaces beyond the single disease. Because of this, the interpretation of NfL may benefit by also considering how neurological symptoms relate to its blood concentration. Here, we review how different neurological symptoms can be associated with blood NfL levels with a practical interpretation of it.
神经丝轻链 (NfL) 是一种非常特异的神经元损伤标志物，与神经元损伤的原因或部位无关。NfL 越来越被认为是神经疾病中疾病活动的可能生物标志物。有几项研究综述了 NfL 在不同疾病中的应用。尽管如此，NfL 是神经元损伤的通用标志物，其解释范围超出了单一疾病。因此，通过考虑神经症状与其血液浓度之间的关系，NfL 的解释可能会受益。在这里，我们回顾了不同的神经症状如何与血液 NfL 水平相关联，并对其进行了实际的解释。
