Shida Naoki, Nakamura Yuto, Atobe Mahito
Department of Chemistry and Life Science, Yokohama National University, 79-5 Tokiwadai, Hodogaya-ku, Yokohama, Kanagawa, Japan.
Chem Rec. 2021 Sep;21(9):2164-2177. doi: 10.1002/tcr.202100016. Epub 2021 Mar 18.
Electrosynthesis and microflow synthesis have become essential tools in their own rights in modern organic synthesis. In this personal account, we summarize our works on the integrated use of these techniques, i. e., electrosynthesis in a flow microreactor. Our group has developed an electrochemical microflow system composed of a pair of electrodes that face each other to form a micrometer-scale gap for the flow path, through which solution passes in laminar flow. By the aid of laminar flow, unprecedented chemo- and electrochemical selectivity has been observed, which is not achievable with conventional batch-type electrochemical cells. In addition, we showcase various unique electrochemical systems and reactions achieved with the flow microreactor, including self-supported electrolysis, efficient paired electrolysis, in situ generation of active species and its flash use, the spaciotemporal control of electropolymerization, and combinatorial screening of the reaction conditions.
电合成和微流合成本身已成为现代有机合成中必不可少的工具。在这篇个人综述中，我们总结了我们在这些技术的综合应用方面的工作，即在流动微反应器中的电合成。我们小组开发了一种电化学微流系统，该系统由一对相互面对的电极组成，形成一个用于流动路径的微米级间隙，溶液以层流形式通过该间隙。借助层流，观察到了前所未有的化学和电化学选择性，这是传统间歇式电化学电池无法实现的。此外，我们展示了用流动微反应器实现的各种独特的电化学系统和反应，包括自支撑电解、高效成对电解、活性物种的原位生成及其快速使用、电聚合的时空控制以及反应条件的组合筛选。
