急性经口暴露后 PCB 11 在小鼠体内的分布。
Disposition of PCB 11 in Mice Following Acute Oral Exposure.
机构信息
Department of Occupational and Environmental Health, College of Public Health, University of Iowa, Iowa City, Iowa 52242-5000, United States.
Department of Molecular Biosciences, School of Veterinary Medicine, University of California Davis, Davis, California 95616, United States.
出版信息
Chem Res Toxicol. 2021 Apr 19;34(4):988-991. doi: 10.1021/acs.chemrestox.1c00067. Epub 2021 Mar 18.
Abstract
PCB 11 (3,3'-dichloro-biphenyl) is an emerging environmental contaminant that represents a public health concern. Here, we investigated the distribution of PCB 11 and its metabolites in mice exposed orally to PCB 11. PCB 11 tissue levels followed the rank order adipose > lung ∼ muscle > liver > brain > blood 4 h after PCB 11 exposure, which varied from the rank order predicted with a composition-based model. We detected hydroxylated and sulfate metabolites in the liver and sulfate and glucuronide metabolites in serum. These findings lay the groundwork for future toxicity studies with PCB 11.
摘要
多氯联苯 11（3,3'-二氯联苯）是一种新兴的环境污染物，引起了公众健康方面的关注。在这里，我们研究了经口暴露于多氯联苯 11 的小鼠中多氯联苯 11 及其代谢物的分布。多氯联苯 11 组织水平在多氯联苯 11 暴露 4 小时后按脂肪组织＞肺组织≈肌肉组织＞肝脏＞大脑＞血液的顺序排列，这与基于组成的模型预测的顺序不同。我们在肝脏中检测到了羟基化和硫酸代谢物，在血清中检测到了硫酸和葡萄糖醛酸代谢物。这些发现为未来的多氯联苯 11 毒性研究奠定了基础。
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