Promotes the Malignancy of Ovarian Cancer Via the Regulation of Hippo and Wnt Pathways.

is a transcription factor that is overexpressed in the early stages of ovarian cancer and has been suggested as a potential biomarker for early detection. In this study, we aimed to examine the role of in invasion and proliferation of ovarian cancer cells. We performed cell viability, colony formation, and invasion assays using ovarian cancer cells treated with siRNA to knock down the gene. The regulatory effects of on proteins involved in the apoptotic, Wnt, Hippo, and retinoblastoma signaling pathways were evaluated by western blotting following repression. In addition, we analyzed data available on Gene Expression Profiling Interactive Analysis for correlations between and , β, , , and . was highly expressed in ovarian cancer cell lines and samples when compared to the nonmalignant tissues. Downregulation of inhibited cell viability and invasion and promoted the phosphorylation of YAP, GSK-3-β, β-catenin, and retinoblastoma. However, cyclin D1, cdk4, and caspase-9 were downregulated when compared to control. Overall, promotes ovarian carcinogenesis via the regulation of Hippo and Wnt pathways