GradCertPharmPrac, Pharmacist, Pharmacy Department, Alfred Health, Melbourne, Australia.
Lead Pharmacist, Pharmacy Department, Alfred Health, Melbourne, Australia; Faculty of Pharmacy and Pharmaceutical Sciences, Monash University, Melbourne, Australia; Emergency and Trauma Centre, Alfred Health, Melbourne, Australia.
J Opioid Manag. 2021 Jan-Feb;17(1):55-61. doi: 10.5055/jom.2021.0613.
The aim of this study was to assess the introduction of an analgesic ladder and targeted education on oxycodone use for patients presenting to the emergency department (ED).
A retrospective pre-post implementation study was conducted. Data were extracted for patients presenting from June to July 2016 (preintervention) and June to July 2017 (post-intervention).
The EDs of a major metropolitan health service and an affiliated community-based hospital.
Patients with back pain where nonpharmacological interventions such as mobilization and physiotherapy are recommended as the mainstay of treatment.
A modified analgesic ladder introduced in May 2017. The ladder promoted the use of simple analgesics such as paracetamol and nonsteroidal anti-inflammatory drug (NSAIDs) prior to opioids and tramadol in preference to oxycodone in selected patients.
MAIN OUTCOME MEASURE(S): The proportion of patients prescribed oxycodone and total doses administered.
There were 107 patients pre and 107 post-intervention included in this study. After implementation of the analgesic ladder, 78 (72.9 percent) preintervention patients and 55 (51.4 percent) post-intervention patients received oxycodone in ED (p = 0.001). The median oxycodone doses administered in the ED was 14 mg (interquartile range: 5-20 mg) and 5 mg (interquartile range: 5-10 mg; p < 0.001), respectively. On discharge from hospital, a prescription for oxycodone was issued for 36 (33.6 percent) patients preintervention and 26 (24.3 percent) patients post-intervention (p = 0.13).
Among patients with back pain, implementation of a modified analgesic ladder was associated with a statistically significant but modest reduction in oxycodone prescription. Consideration of multifaceted interventions to produce major and sustained changes in opioid prescribing is required.
本研究旨在评估为就诊于急诊部(ED)的患者引入止痛阶梯和对羟考酮使用进行针对性教育的效果。
这是一项回顾性实施前后研究。从 2016 年 6 月至 7 月(干预前)和 2017 年 6 月至 7 月(干预后)提取就诊于 ED 的患者数据。
一家主要大都市卫生服务机构和一家附属社区医院的 ED。
患有背痛的患者,这些患者的主要治疗方法是采用非药物干预措施,如活动和物理疗法。
2017 年 5 月引入改良的止痛阶梯。该阶梯提倡在选择的患者中优先使用简单的镇痛药,如对乙酰氨基酚和非甾体抗炎药(NSAIDs),而非阿片类药物和曲马多,而不是羟考酮。
开处方羟考酮的患者比例和给予的总剂量。
本研究共纳入 107 例干预前和 107 例干预后患者。实施止痛阶梯后,78 例(72.9%)干预前患者和 55 例(51.4%)干预后患者在 ED 接受羟考酮治疗(p=0.001)。ED 给予羟考酮的中位数剂量分别为 14mg(四分位间距:5-20mg)和 5mg(四分位间距:5-10mg;p<0.001)。出院时,干预前开具羟考酮处方的患者为 36 例(33.6%),干预后为 26 例(24.3%)(p=0.13)。
在背痛患者中,实施改良的止痛阶梯与羟考酮处方的显著但适度减少相关。需要考虑多方面的干预措施,以产生阿片类药物处方的重大和持续变化。