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在急诊部门引入改良镇痛阶梯:对曲马多治疗腰痛的影响。

Introduction of a modified analgesic ladder in the emergency depart-ment: Effect on oxycodone use for back pain.

机构信息

GradCertPharmPrac, Pharmacist, Pharmacy Department, Alfred Health, Melbourne, Australia.

Lead Pharmacist, Pharmacy Department, Alfred Health, Melbourne, Australia; Faculty of Pharmacy and Pharmaceutical Sciences, Monash University, Melbourne, Australia; Emergency and Trauma Centre, Alfred Health, Melbourne, Australia.

出版信息

J Opioid Manag. 2021 Jan-Feb;17(1):55-61. doi: 10.5055/jom.2021.0613.

Abstract

OBJECTIVE

The aim of this study was to assess the introduction of an analgesic ladder and targeted education on oxycodone use for patients presenting to the emergency department (ED).

DESIGN

A retrospective pre-post implementation study was conducted. Data were extracted for patients presenting from June to July 2016 (preintervention) and June to July 2017 (post-intervention).

SETTING

The EDs of a major metropolitan health service and an affiliated community-based hospital.

PARTICIPANTS

Patients with back pain where nonpharmacological interventions such as mobilization and physiotherapy are recommended as the mainstay of treatment.

INTERVENTIONS

A modified analgesic ladder introduced in May 2017. The ladder promoted the use of simple analgesics such as paracetamol and nonsteroidal anti-inflammatory drug (NSAIDs) prior to opioids and tramadol in preference to oxycodone in selected patients.

MAIN OUTCOME MEASURE(S): The proportion of patients prescribed oxycodone and total doses administered.

RESULTS

There were 107 patients pre and 107 post-intervention included in this study. After implementation of the analgesic ladder, 78 (72.9 percent) preintervention patients and 55 (51.4 percent) post-intervention patients received oxycodone in ED (p = 0.001). The median oxycodone doses administered in the ED was 14 mg (interquartile range: 5-20 mg) and 5 mg (interquartile range: 5-10 mg; p < 0.001), respectively. On discharge from hospital, a prescription for oxycodone was issued for 36 (33.6 percent) patients preintervention and 26 (24.3 percent) patients post-intervention (p = 0.13).

CONCLUSIONS

Among patients with back pain, implementation of a modified analgesic ladder was associated with a statistically significant but modest reduction in oxycodone prescription. Consideration of multifaceted interventions to produce major and sustained changes in opioid prescribing is required.

摘要

目的

本研究旨在评估为就诊于急诊部(ED)的患者引入止痛阶梯和对羟考酮使用进行针对性教育的效果。

设计

这是一项回顾性实施前后研究。从 2016 年 6 月至 7 月(干预前)和 2017 年 6 月至 7 月(干预后)提取就诊于 ED 的患者数据。

地点

一家主要大都市卫生服务机构和一家附属社区医院的 ED。

参与者

患有背痛的患者,这些患者的主要治疗方法是采用非药物干预措施,如活动和物理疗法。

干预措施

2017 年 5 月引入改良的止痛阶梯。该阶梯提倡在选择的患者中优先使用简单的镇痛药,如对乙酰氨基酚和非甾体抗炎药(NSAIDs),而非阿片类药物和曲马多,而不是羟考酮。

主要观察指标

开处方羟考酮的患者比例和给予的总剂量。

结果

本研究共纳入 107 例干预前和 107 例干预后患者。实施止痛阶梯后,78 例(72.9%)干预前患者和 55 例(51.4%)干预后患者在 ED 接受羟考酮治疗(p=0.001)。ED 给予羟考酮的中位数剂量分别为 14mg(四分位间距:5-20mg)和 5mg(四分位间距:5-10mg;p<0.001)。出院时,干预前开具羟考酮处方的患者为 36 例(33.6%),干预后为 26 例(24.3%)(p=0.13)。

结论

在背痛患者中,实施改良的止痛阶梯与羟考酮处方的显著但适度减少相关。需要考虑多方面的干预措施,以产生阿片类药物处方的重大和持续变化。

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