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吲哚美辛喷雾对癌症患者药物性口腔黏膜炎疼痛的镇痛效果：一项单臂横断面研究。

Analgesic effects of indomethacin spray on drug-induced oral mucositis pain in patients with cancer: A single-arm cross-sectional study.

机构信息

Department of Dentistry and Oral Surgery, National Hospital Organization Hokkaido Cancer Center, Sapporo, Japan.

Department of Pharmacy, National Hospital Organization Hokkaido Cancer Center, Sapporo, Japan.

出版信息

Spec Care Dentist. 2021 Jul;41(4):498-504. doi: 10.1111/scd.12587. Epub 2021 Mar 18.

DOI:10.1111/scd.12587
PMID:33735535
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8360043/
Abstract

AIMS

Symptomatic treatment is insufficient for chemotherapy- or targeted therapy-induced oral mucositis (OM) pain, and benzydamine mouthwash is not commercially available in Japan. We evaluated the analgesic effects of an in-hospital preparation of 0.25% indomethacin spray (IMS) on anticancer drug-induced OM pain.

METHODS

This single-arm prospective trial enrolled 20 patients (median age 62.0 years) with OM and numerical rating scale scores of ≥5 who were undergoing chemotherapy or targeted therapy in our hospital. Pain scores were recorded using a visual analog scale (VAS) before and 30 min after IMS administration. Pain relief (PR) scores were recorded at 15, 30, and 60 min after IMS administration; total PR after 60 min (TOTPAR ) was calculated, and the mean PR score after 3 days (PR ) was determined.

RESULTS

The median (interquartile range) OM grade of the participants was 2.0 (2.0-2.3). The VAS score decreased significantly at 30 min after IMS administration (p = .001). The median (interquartile range) TOTPAR and PR were 6.0 (3.8-7.3) and 2.0 (2.0-3.0), respectively.

CONCLUSIONS

IMS helped improve patients' quality of life. The risk of systemic adverse effects was low because of the low dose administered. IMS effectively relieved anticancer drug-induced OM pain and may be useful for immediate self-medication.

摘要

目的

化疗或靶向治疗引起的口腔黏膜炎（OM）疼痛的对症治疗效果有限，且苄达明含漱液在日本并未上市。我们评估了院内自制 0.25%吲哚美辛喷雾剂（IMS）对癌症药物引起的 OM 疼痛的镇痛效果。

方法

这项单臂前瞻性试验纳入了 20 名 OM 患者（中位年龄 62.0 岁），这些患者在我院接受化疗或靶向治疗，其 OM 疼痛的数字评分量表（NRS）评分≥5 分。在使用 IMS 前后通过视觉模拟量表（VAS）记录疼痛评分。在使用 IMS 后 15、30 和 60 分钟记录疼痛缓解（PR）评分；计算 60 分钟后的总 PR 评分（TOTPAR），并确定 3 天后的平均 PR 评分（PR）。

结果

参与者的 OM 分级中位数（四分位距）为 2.0（2.0-2.3）。使用 IMS 后 30 分钟，VAS 评分显著下降（p=.001）。TOTPAR 和 PR 的中位数（四分位距）分别为 6.0（3.8-7.3）和 2.0（2.0-3.0）。

结论

IMS 有助于提高患者的生活质量。由于给药剂量低，全身不良反应的风险较低。IMS 能有效缓解癌症药物引起的 OM 疼痛，可能有助于即时自我治疗。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/261c/8360043/ba43db39b6bc/SCD-41-498-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/261c/8360043/15abc5509ff3/SCD-41-498-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/261c/8360043/f81f5e34c8ae/SCD-41-498-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/261c/8360043/ba43db39b6bc/SCD-41-498-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/261c/8360043/15abc5509ff3/SCD-41-498-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/261c/8360043/f81f5e34c8ae/SCD-41-498-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/261c/8360043/ba43db39b6bc/SCD-41-498-g003.jpg

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本文引用的文献

1
The Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) Statement: guidelines for reporting observational studies.《流行病学观察研究报告的强化（STROBE）声明：观察研究报告指南》。
Int J Surg. 2014 Dec;12(12):1495-9. doi: 10.1016/j.ijsu.2014.07.013. Epub 2014 Jul 18.
2
Chemotherapy or radiation-induced oral mucositis.化疗或放疗引起的口腔黏膜炎。
Dent Clin North Am. 2014 Apr;58(2):341-9. doi: 10.1016/j.cden.2013.12.005.
3
MASCC/ISOO clinical practice guidelines for the management of mucositis secondary to cancer therapy.
MASCC/ISOO 临床实践指南：癌症治疗相关黏膜炎的管理。
Cancer. 2014 May 15;120(10):1453-61. doi: 10.1002/cncr.28592. Epub 2014 Feb 25.
4
Emerging evidence on the pathobiology of mucositis.口腔黏膜炎的发病机制的新证据。
Support Care Cancer. 2013 Jul;21(7):2075-83. doi: 10.1007/s00520-013-1810-y. Epub 2013 Apr 21.
5
Efficacy of topical phenytoin on chemotherapy-induced oral mucositis; a pilot study.局部苯妥英钠治疗化疗诱导性口腔黏膜炎的疗效：一项初步研究。
Daru. 2010;18(1):46-50.
6
Severe oral mucositis associated with cancer therapy: impact on oral functional status and quality of life.癌症治疗相关的严重口腔黏膜炎：对口腔功能状态和生活质量的影响。
Support Care Cancer. 2010 Nov;18(11):1477-85. doi: 10.1007/s00520-009-0771-7. Epub 2009 Nov 15.
7
Management of oral mucositis in patients who have cancer.癌症患者口腔黏膜炎的管理
Dent Clin North Am. 2008 Jan;52(1):61-77, viii. doi: 10.1016/j.cden.2007.10.002.
8
Topical NSAIDs for acute pain: a meta-analysis.用于急性疼痛的外用非甾体抗炎药：一项荟萃分析。
BMC Fam Pract. 2004 May 17;5:10. doi: 10.1186/1471-2296-5-10.
9
The pathobiology of mucositis.黏膜炎的病理生物学
Nat Rev Cancer. 2004 Apr;4(4):277-84. doi: 10.1038/nrc1318.
10
[The effects of indomethacin spray on the pain of stomatitis in the patients for hematopoietic stem cell transplantation].[吲哚美辛喷雾剂对造血干细胞移植患者口腔炎疼痛的影响]
Yakugaku Zasshi. 2003 Dec;123(12):1023-9. doi: 10.1248/yakushi.123.1023.