School of Persian Medicine, Tehran University of Medical Sciences, Tehran, Iran.
Evidence-based Phytotherapy and Complementary Medicine Research Center, Alborz University of Medical Sciences, Karaj, Iran; Department of Pharmacognosy, Faculty of Pharmacy, Alborz University of Medical Sciences, Karaj, Iran.
Complement Ther Clin Pract. 2021 May;43:101361. doi: 10.1016/j.ctcp.2021.101361. Epub 2021 Mar 11.
Gastroesophageal reflux disease (GERD) as one of the most common ailments of gastrointestinal system diminishes quality of life and impairs physical functioning and work productivity. Proton-pump inhibitors (PPIs), such as omeprazole play a more dominant role in amelioration of GERD symptoms; nonetheless, there is a growing concern about their side effects. According to traditional Persian medicine (TPM), the use of rose oil is recommended to alleviate GERD symptoms.
Therefore, a randomized double-blind controlled trial was performed on 70 subjects who were randomly enrolled in two groups and received either rose oil softgel or omeprazole capsule combined with the placebo. Data were collected within 3 sessions of visit using the Mayo-gastroesophageal reflux questionnaire (GERQ).
Although, our findings showed that reflux symptoms were decreased in both groups after receiving medicine and the decrement was significant in treatment group, before and after the intervention, this decrease was not significant between two groups.
Given that the rose oil used in this study was produced according to the Iranian method and effective ingredients of Rosa damascena were preserved in sesame oil in production process, it seems that effectiveness of this product can be due to its tonic and enlivening properties. Consumption of rose oil soft capsule alleviates cardinal GERD symptoms similar to omeprazole. It seems that rose oil can have the same effects as PPIs in treatment of GERD but with no side effects due to its different mechanisms of action.
胃食管反流病（GERD）是最常见的胃肠道疾病之一，它降低了生活质量，并损害了身体机能和工作生产力。质子泵抑制剂（PPIs），如奥美拉唑，在改善 GERD 症状方面发挥着更主导的作用；然而，人们越来越关注它们的副作用。根据传统的波斯医学（TPM），建议使用玫瑰油来缓解 GERD 症状。
因此，我们进行了一项随机双盲对照试验，共有 70 名受试者被随机分为两组，分别接受玫瑰油软胶囊或奥美拉唑胶囊联合安慰剂治疗。使用梅奥胃食管反流问卷（GERQ）在 3 次就诊中收集数据。
尽管我们的研究结果表明，两组在接受药物治疗后反流症状均有所减轻，且治疗组的减轻程度更为显著，但干预前后两组间的这种减轻程度并不显著。
鉴于本研究中使用的玫瑰油是按照伊朗方法生产的，并且在生产过程中有效成分得以保存在芝麻油中，因此，该产品的有效性可能与其滋补和提神的特性有关。玫瑰油软胶囊的消费可缓解 GERD 的主要症状，与奥美拉唑相似。由于作用机制不同，玫瑰油似乎可以与 PPIs 一样治疗 GERD，而没有副作用。
