Lundbeck F, Bruun E, Finnerup B, Christophersen I S
Urological Department K, Aarhus Municipal Hospital, Denmark.
J Urol. 1988 Jun;139(6):1212-3. doi: 10.1016/s0022-5347(17)42863-1.
A total of 64 consecutive patients with noninvasive bladder tumors (stage Ta) between 1977 and 1983 underwent treatment with intravesical instillation of doxorubicin. The total response rate was 85 per cent and 57 per cent of the patients had a complete response after 16 weekly instillations. Half of the patients with a complete response had recurrences within 12 to 16 months. Ten per cent of all patients had an invasive tumor during the observation period. We conclude that doxorubicin can render some patients with noninvasive bladder tumors (stage Ta) free of disease but there currently is nothing to indicate that the same results could not be obtained by transurethral resection.
1977年至1983年间，共有64例连续性非浸润性膀胱肿瘤（Ta期）患者接受了阿霉素膀胱内灌注治疗。总缓解率为85%，57%的患者在每周一次共16次灌注后获得完全缓解。完全缓解的患者中有一半在12至16个月内复发。在观察期内，所有患者中有10%发生浸润性肿瘤。我们得出结论，阿霉素可使部分非浸润性膀胱肿瘤（Ta期）患者无疾病状态，但目前没有证据表明经尿道切除术不能取得同样的结果。
