Tokyo Saiseikai Central Hospital, Tokyo, Japan.
St. Marianna University, Kawasaki, Kanagawa, Japan.
J Investig Med High Impact Case Rep. 2021 Jan-Dec;9:2324709621999226. doi: 10.1177/2324709621999226.
Intravascular large B-cell lymphoma (IVLBCL) is a rare form of diffuse LBCL. The patient was a 71-year-old female admitted to our hospital with hypoxia. On admission, chest computed tomography revealed a ground-glass opacity. Interstitial pneumonia associated with systemic scleroderma was suspected because of positive anti-centromere antibody. Thereafter, steroid pulse therapy and plasma exchange were performed. Although ground-glass opacity improved, bilateral pleural effusion appeared, so we performed a random skin biopsy because of her elevated serum lactate dehydrogenase and soluble interleukin-2 receptor levels. The patient was diagnosed with IVLBCL with symptoms improving after 6 cycles of rituximab plus chemotherapy treatment.
血管内大 B 细胞淋巴瘤（IVLBCL）是一种罕见的弥漫性大 B 细胞淋巴瘤。患者为 71 岁女性，因缺氧入院。入院时，胸部计算机断层扫描显示磨玻璃影。由于抗着丝点抗体阳性，怀疑患有与系统性硬皮病相关的间质性肺炎。此后，进行了类固醇脉冲治疗和血浆置换。尽管磨玻璃影有所改善，但出现双侧胸腔积液，因此由于血清乳酸脱氢酶和可溶性白细胞介素 2 受体水平升高，我们进行了随机皮肤活检。患者被诊断为 IVLBCL，在接受利妥昔单抗联合化疗治疗 6 个周期后症状改善。
