Dpt. Medical-Surgical Therapeutics, Medical School, University of Extremadura, Badajoz, Spain.
Eating Disorders Unit, Institute of Mental Disorders, Health Service of Extremadura, Badajoz, Spain.
Gene. 2021 May 30;783:145572. doi: 10.1016/j.gene.2021.145572. Epub 2021 Mar 16.
Our aim was to determine whether variability in the fat mass obesity (FTO) gene locus, consistently related to obesity, affects the risk of eating disorders (ED) and/or the psychopathology displayed by these patients. We analyzed 26 tag-single nucleotide polymorphisms (SNPs) that capture FTO variability in 352 ED patients [233 with Anorexia Nervosa (AN) and 119 with binge-eating] and 396 controls. Psychopathological symptoms and traits were evaluated by the Eating Disorders Inventory Test 2 (EDI-2) and Symptoms Checklist 90 Revised (SCL-90R) questionnaires. No associations were found for ED risk. The rs7205987 CC genotype correlated with higher scores in all but one of the EDI-2 scales in the AN group. Associations with Bulimia (p = 0.0019) and Interoceptive Awareness (p = 0.00007) retained significance after False Discovery Rate (FDR) correction for multiple testing. A 3-SNP sliding window analysis showed that FTO haplotypes were again highly associated with Interoceptive Awareness (rs9921255/rs6499662/rs7205987 haplotype; FDR-q = 0.04), Bulimia (rs1125338/rs2192872/rs708258; FDR-q = 0.00037), and Maturity Fears (rs708258/rs12599672/rs11076017; FDR-q = 0.041). In addition, a distal region of the gene between rs9924877 (position 53947509) and rs2192872 (54040715) was linked to Anxiety, Depression and Phobic Anxiety in AN patients, with FDR-q values ranging from 0.023 to 0.045. The results suggest that the FTO gene might be an important locus regarding traits and psychopathological symptoms often displayed by AN patients.
我们的目的是确定肥胖相关的脂肪质量肥胖（FTO）基因座的变异性是否会影响进食障碍（ED）的风险和/或这些患者表现出的精神病理学。我们分析了 352 名 ED 患者[233 名神经性厌食症（AN）和 119 名暴食症]和 396 名对照者中捕获 FTO 变异性的 26 个标签单核苷酸多态性（SNP）。通过饮食失调清单 2 （EDI-2）和症状检查表 90 修订版（SCL-90R）问卷评估精神病理学症状和特征。未发现与 ED 风险相关的关联。rs7205987CC 基因型与 AN 组中除一项外的所有 EDI-2 量表的评分均相关。在进行假发现率（FDR）校正后，与贪食症（p=0.0019）和内脏感知（p=0.00007）的关联仍然具有统计学意义。3-SNP 滑动窗口分析显示，FTO 单倍型与内脏感知（rs9921255/rs6499662/rs7205987 单倍型；FDR-q=0.04）、贪食症（rs1125338/rs2192872/rs708258；FDR-q=0.00037）和成熟恐惧（rs708258/rs12599672/rs11076017；FDR-q=0.041）再次高度相关。此外，rs9924877（位置 53947509）和 rs2192872（54040715）之间基因的远端区域与 AN 患者的焦虑、抑郁和恐惧症有关，FDR-q 值范围为 0.023 至 0.045。结果表明，FTO 基因可能是一个重要的基因座，与 AN 患者经常表现出的特征和精神病理学症状有关。
