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"Diagnosis on the Dock" 项目:一个主动筛查计划,用于诊断下船难民中的肺结核病和新的 SEI 模型。

"Diagnosis on the Dock" project: A proactive screening program for diagnosing pulmonary tuberculosis in disembarking refugees and new SEI model.

机构信息

Unit of Infectious Diseases, Department of Clinical and Experimental Medicine, ARNAS Garibaldi Nesima Hospital, University of Catania, Catania, Italy.

Unit of Infectious Diseases, Department of Clinical and Experimental Medicine, ARNAS Garibaldi Nesima Hospital, University of Catania, Catania, Italy.

出版信息

Int J Infect Dis. 2021 May;106:98-104. doi: 10.1016/j.ijid.2021.03.032. Epub 2021 Mar 15.

Abstract

OBJECTIVE

From 2011 to 2017, the total number of refugees arriving in Europe, particularly in Italy, climbed dramatically. Our aim was to diagnose pulmonary TB in migrants coming from the African coast using a clinical-based port of arrival (PoA) screening program.

METHODS

From 2016 to 2018, migrants coming via the Mediterranean Route were screened for body temperature and the presence of cough directly on the dock: if they were feverish with productive cough, their sputum was examined with NAAT; with a dry cough, they underwent Chest-X-ray (CXR). Those migrants with positive NAAT or CXR suggestive for TB were admitted to our ward. In addition, we plotted an SEI simulation of our project to evaluate the epidemiological impact of our screening.

RESULTS

Out of 33.676 disembarking migrants, 314 (0.9%) had fever and cough: 80 (25.47%) with productive cough underwent NAAT in sputum, and 16 were positive for TB; 234 (74.52%) with dry cough had a CXR examination, and 39 were suggestive of TB, later confirmed by mycobacterial culture. The SEI-new model analysis demonstrated that our screening program significantly reduced TB spreading all over the country.

CONCLUSIONS

For possible future high migrant flows, PoA screening for TB has to be considered feasible and effective in decreasing TB spreading.

摘要

目的

2011 年至 2017 年期间,抵达欧洲的难民总数,尤其是意大利,急剧攀升。我们的目标是通过基于临床的抵达港(PoA)筛查计划,对来自非洲海岸的移民中的肺结核进行诊断。

方法

2016 年至 2018 年期间,通过地中海航线抵达的移民在码头直接接受体温和咳嗽情况筛查:如果有发热和咳嗽,他们的痰液将进行核酸扩增检测(NAAT)检查;如果有干咳,则进行胸部 X 光检查(CXR)。对于 NAAT 或 CXR 提示肺结核的移民,他们被收治入院。此外,我们还绘制了我们项目的 SEI 模拟图,以评估我们筛查的流行病学影响。

结果

在 33676 名下船移民中,有 314 人(0.9%)有发热和咳嗽:80 人(25.47%)有湿咳,进行了痰液 NAAT 检查,其中 16 人结核分枝杆菌检测阳性;234 人(74.52%)有干咳,进行了 CXR 检查,其中 39 人提示患有结核病,后来通过分枝杆菌培养得到证实。SEI-新模型分析表明,我们的筛查计划显著减少了结核病在全国的传播。

结论

对于未来可能出现的大量移民潮,基于抵达港的结核病筛查必须被认为是可行和有效的,可减少结核病的传播。

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