Department of Kinesiology, University of Wisconsin-Madison, Madison, WI, United States of America.
Department of Medicine, University of Alabama at Birmingham, Birmingham, AL, United States of America.
Contemp Clin Trials. 2021 May;104:106358. doi: 10.1016/j.cct.2021.106358. Epub 2021 Mar 15.
Because medication adherence is linked to better diabetes outcomes, numerous interventions have aimed to improve adherence. However, suboptimal adherence persists and necessitate continued research into intervention strategies. This study evaluated the effectiveness of an intervention that combined storytelling and peer support to improve medication adherence and health outcomes in adults with diabetes.
Living Well with Diabetes was a cluster randomized controlled trial. Intervention participants received a six-month, 11-session peer-delivered behavioral diabetes self-care program over the phone. Control participants received a self-paced general health program. Outcomes were changes in medication adherence and physiologic measures (hemoglobin A1c, systolic blood pressure, low-density lipoprotein cholesterol, body mass index).
Of the 403 participants with follow-up data, mean age was 57 (±SD 11), 78% were female, 91% were African American, 56.4% had high school education or less, and 70% had an annual income of < $20,000. At follow-up, compared to controls, intervention participants had greater improvement in medication adherence (β = -0.25 [95% CI -0.35, -0.15]). Physiologic measures did not change significantly in either group. Intervention participants had significant improvements in beliefs about the necessity of medications (β = 0.87 [95% CI 0.27, 1.47]) concerns about the negative effects of medication (β = -0.91 [95% CI -1.35, -0.47]), and beliefs that medications are harmful (β = -0.50 [95% CI -0.89, -0.10]). In addition, medication use self-efficacy significantly improved in intervention participants (β = 1.0 [95% CI 0.23, 1.76]). 473 individuals were enrolled in the study and randomized.
Living Well intervention resulted in improved medication adherence, medication beliefs, and medication use self-efficacy but not improved risk factor levels.
由于药物依从性与更好的糖尿病结果相关,因此许多干预措施旨在提高依从性。然而,依从性仍不理想,需要继续研究干预策略。本研究评估了一种将故事叙述和同伴支持相结合以改善糖尿病患者药物依从性和健康结果的干预措施的有效性。
“与糖尿病共同生活”是一项集群随机对照试验。干预组参与者接受了为期六个月的 11 次电话进行的同伴提供的行为糖尿病自我护理计划。对照组参与者接受了自我指导的一般健康计划。结局为药物依从性和生理指标(糖化血红蛋白、收缩压、低密度脂蛋白胆固醇、体重指数)的变化。
在有随访数据的 403 名参与者中,平均年龄为 57(±11)岁,78%为女性,91%为非裔美国人,56.4%具有高中或以下学历,70%的人年收入<$20000。与对照组相比,随访时干预组的药物依从性改善更大(β=-0.25[95%CI-0.35,-0.15])。两组的生理指标均无显著变化。干预组参与者对药物必要性的信念(β=0.87[95%CI0.27,1.47])、对药物负面效应的担忧(β=-0.91[95%CI-1.35,-0.47])和对药物有害的信念(β=-0.50[95%CI-0.89,-0.10])均显著改善。此外,干预组的药物使用自我效能显著提高(β=1.0[95%CI0.23,1.76])。该研究共纳入 473 名个体并进行了随机分组。
“共同生活”干预措施可改善药物依从性、药物信念和药物使用自我效能,但不能改善风险因素水平。