遗传推断的端粒长度与睾丸生殖细胞肿瘤风险。
Genetically Inferred Telomere Length and Testicular Germ Cell Tumor Risk.
机构信息
Division of Cancer Epidemiology and Genetics, NCI, Rockville, Maryland.
Cancer Prevention Fellowship Program, Division of Cancer Prevention, NCI, Rockville, Maryland.
出版信息
Cancer Epidemiol Biomarkers Prev. 2021 Jun;30(6):1275-1278. doi: 10.1158/1055-9965.EPI-20-1775. Epub 2021 Mar 18.
BACKGROUND
Studies evaluating the association between peripheral blood leukocyte telomere length (LTL) and testicular germ cell tumor (TGCT) risk have produced conflicting results.
METHODS
Using available genotype data from the Testicular Cancer Consortium (TECAC), polygenic risk score and Mendelian randomization analyses of genetic variants previously associated with LTL were used to assess potential etiologic associations between telomere length and TGCT risk.
RESULTS
Genetically inferred telomere length was not associated with TGCT risk among 2,049 cases and 6,921 controls with individual-level genotype data (OR, 1.02; 95% confidence interval, 0.97-1.07). Mendelian randomization analyses using summary statistic data further indicated no evidence for an association between telomere length and TGCT risk among all available TECAC participants (3,558 cases and 13,971 controls).
CONCLUSIONS
Our analyses in the largest molecular genetic testicular cancer study to date provide no evidence for an association between genetically inferred peripheral blood LTL and TGCT risk.
IMPACT
The lack of evidence for an overall association indicates that peripheral blood LTL is likely not a strong biomarker for TGCT risk.
背景
评估外周血白细胞端粒长度（LTL）与睾丸生殖细胞肿瘤（TGCT）风险之间关联的研究结果相互矛盾。
方法
利用睾丸癌联盟（TECAC）的可用基因型数据，对先前与 LTL 相关的遗传变异进行多基因风险评分和孟德尔随机化分析，以评估端粒长度与 TGCT 风险之间潜在的病因关联。
结果
在具有个体水平基因型数据的 2049 例病例和 6921 例对照中，遗传推断的端粒长度与 TGCT 风险无关（OR，1.02；95%置信区间，0.97-1.07）。使用汇总统计数据进行的孟德尔随机化分析进一步表明，在所有可用的 TECAC 参与者中，端粒长度与 TGCT 风险之间没有关联（3558 例病例和 13971 例对照）。
结论
我们在迄今为止最大的分子遗传学睾丸癌研究中的分析结果表明，遗传推断的外周血 LTL 与 TGCT 风险之间没有关联。
影响
缺乏总体关联的证据表明，外周血 LTL 不太可能是 TGCT 风险的一个强有力的生物标志物。
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