Ginsburg Amy Sarah, Nisar Imran, Madrid Lola, Lenahan Jennifer L, Balouch Benazir, Vitorino Pio, Hwang Jun, Lamorte Alessandro, Kanth Neel, Bila Rubao, Valente Marta, Varo Rosauro, May Susanne, Bassat Quique, Jehan Fyezah, Volpicelli Giovanni
University of Washington, Seattle, WA, USA.
University of Washington Clinical Trial Center, Building 29, Suite 250, 6200 NE 74th Street, Seattle, WA, 98115, USA.
Sci Rep. 2021 Mar 18;11(1):6262. doi: 10.1038/s41598-021-85485-y.
Lung ultrasound (LUS) is a promising point-of-care imaging technology for diagnosing and managing pneumonia. We sought to explore serial LUS examinations in children with chest-indrawing pneumonia in resource-constrained settings and compare their clinical and LUS imaging courses longitudinally. We conducted a prospective, observational study among children aged 2 through 23 months with World Health Organization Integrated Management of Childhood Illness chest-indrawing pneumonia and among children without fast breathing, chest indrawing or fever (no pneumonia cohort) at 2 district hospitals in Mozambique and Pakistan. We assessed serial LUS at enrollment, 2, 6, and 14 days, and performed a secondary analysis of enrolled children's longitudinal clinical and imaging courses. By Day 14, the majority of children with chest-indrawing pneumonia and consolidation on enrollment LUS showed improvement on follow-up LUS (100% in Mozambique, 85.4% in Pakistan) and were clinically cured (100% in Mozambique, 78.0% in Pakistan). In our cohort of children with chest-indrawing pneumonia, LUS imaging often reflected the clinical course; however, it is unclear how serial LUS would inform the routine management of non-severe chest-indrawing pneumonia.
肺部超声（LUS）是一种用于诊断和管理肺炎的很有前景的床旁成像技术。我们试图在资源有限的环境中探索对有胸凹陷性肺炎的儿童进行系列LUS检查，并纵向比较他们的临床和LUS成像病程。我们在莫桑比克和巴基斯坦的两家地区医院，对年龄在2至23个月、患有世界卫生组织儿童疾病综合管理中定义的胸凹陷性肺炎的儿童，以及没有呼吸急促、胸凹陷或发热的儿童（无肺炎队列）进行了一项前瞻性观察研究。我们在入组时、第2天、第6天和第14天评估系列LUS，并对入组儿童的纵向临床和成像病程进行了二次分析。到第14天，大多数入组LUS时有胸凹陷性肺炎和实变的儿童在随访LUS时显示有改善（莫桑比克为100%，巴基斯坦为85.4%），并且临床治愈（莫桑比克为100%，巴基斯坦为78.0%）。在我们有胸凹陷性肺炎的儿童队列中，LUS成像常常反映临床病程；然而，尚不清楚系列LUS如何为非重症胸凹陷性肺炎的常规管理提供信息。
