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某些香豆素和2-氨基-3-腈基硒吩衍生物在前列腺癌中的细胞毒性和凋亡潜力

Cytotoxic and apoptotic potential of some coumarin and 2-amino-3-carbonitrile selenophene derivatives in prostate cancer.

作者信息

Yildirim Metin, Ersatir Mehmet, Arslan Badel, Gİray Elife Sultan

机构信息

Department of Pharmacy Services, Vocational School of Health Services, Tarsus University, Mersin Turkey.

Department of Chemistry, Arts and Science Faculty, Çukurova University, Adana Turkey.

出版信息

Turk J Chem. 2021 Feb 17;45(1):192-198. doi: 10.3906/kim-2008-56. eCollection 2021.

DOI:10.3906/kim-2008-56
PMID:33737857
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7955924/
Abstract

3-acetyl coumarin derivatives (1a-d) are formed as a result of condensation of salicylaldehyde derivatives and ethyl acetoacetate and were converted into coumarin-selenophene hybrid compounds (2a-d) in the basic medium by modified Gewald reaction in the presence of malononitrile and selenium. Products are characterized by nuclear magnetic resonance (NMR). The prepared compounds are screened for their anticancer activity against DU-145 cell line. In addition, selected target compounds are evaluated for apoptosis and oxidative stress on DU-145 (prostate carcinoma) cell lines.

摘要

3-乙酰基香豆素衍生物（1a - d）是水杨醛衍生物与乙酰乙酸乙酯缩合反应的产物，并在碱性介质中，通过在丙二腈和硒存在下的改良盖瓦尔德反应转化为香豆素 - 硒吩杂化化合物（2a - d）。产物通过核磁共振（NMR）进行表征。对所制备的化合物针对DU - 145细胞系进行抗癌活性筛选。此外，对选定的目标化合物针对DU - 145（前列腺癌）细胞系的凋亡和氧化应激进行评估。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5730/7955924/991c5e374200/turkjchem-45-192-fig002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5730/7955924/d870f74773da/turkjchem-45-192-fig001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5730/7955924/991c5e374200/turkjchem-45-192-fig002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5730/7955924/d870f74773da/turkjchem-45-192-fig001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5730/7955924/991c5e374200/turkjchem-45-192-fig002.jpg

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