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1-Pyrazolyl-5,6-Disubstituted Indazole Derivatives as LRRK2 Inhibitors for Treating Parkinson's Disease.

作者信息

Sabnis Ram W

机构信息

Smith, Gambrell & Russell LLP, 1230 Peachtree Street NE, Suite 3100, Atlanta, Georgia 30309, United States.

出版信息

ACS Med Chem Lett. 2021 Feb 5;12(3):310-311. doi: 10.1021/acsmedchemlett.1c00054. eCollection 2021 Mar 11.

Abstract
摘要

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本文引用的文献

1
LRRK2 at the pre-synaptic site: A 16-years perspective.
J Neurochem. 2021 Apr;157(2):297-311. doi: 10.1111/jnc.15240. Epub 2021 Feb 5.
2
New hopes for disease modification in Parkinson's Disease.
Neuropharmacology. 2020 Jul;171:108085. doi: 10.1016/j.neuropharm.2020.108085. Epub 2020 Apr 13.
3
Advances in elucidating the function of leucine-rich repeat protein kinase-2 in normal cells and Parkinson's disease.
Curr Opin Cell Biol. 2020 Apr;63:102-113. doi: 10.1016/j.ceb.2020.01.001. Epub 2020 Feb 7.
4
Immunotherapy for Parkinson's disease.
Neurobiol Dis. 2020 Apr;137:104760. doi: 10.1016/j.nbd.2020.104760. Epub 2020 Jan 21.
5
Leucine-rich repeat kinase 2 and lysosomal dyshomeostasis in Parkinson disease.
J Neurochem. 2020 Feb;152(3):273-283. doi: 10.1111/jnc.14908. Epub 2019 Nov 24.
6
Parkinson disease.
Eur J Neurol. 2020 Jan;27(1):27-42. doi: 10.1111/ene.14108. Epub 2019 Nov 27.

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