Lurvink Robin J, Rijken Anouk, Bakkers Checca, Aarts Mieke J, Kunst Peter W A, van de Borne Ben E, van Erning Felice N, de Hingh Ignace H J T
Department of Surgery, Catharina Hospital, PO Box 1350, 5602 ZA, Eindhoven, The Netherlands.
Department of Research and Development, Netherlands Comprehensive Cancer Organisation (IKNL), Utrecht, The Netherlands.
Clin Exp Metastasis. 2021 Jun;38(3):295-303. doi: 10.1007/s10585-021-10085-z. Epub 2021 Mar 18.
Peritoneal metastases (PM) from lung cancer are rare and it is unknown how they affect the prognosis of patients with lung cancer. This population-based study aimed to assess the incidence, associated factors, treatment and prognosis of PM from lung cancer. Data from the Netherlands Cancer Registry were used. All patients diagnosed with lung cancer between 2008 and 2018 were included. Logistic regression analysis was performed to identify factors associated with the presence of PM. Cox regression analysis was performed to identify factors associated with the overall survival (OS) of patients with PM. Between 2008 and 2018, 129,651 patients were diagnosed with lung cancer, of whom 2533 (2.0%) patients were diagnosed with PM. The European Standardized Rate of PM increased significantly from 0.6 in 2008 to 1.4 in 2018 (p < 0.001). Age between 50 and 74 years, T3-4 tumour stage, N2-3 nodal stage, tumour morphology of a small cell lung cancer or adenocarcinoma, and the presence of systemic metastases were associated with the presence of PM. The median OS of patients with PM was 2.5 months. Older age, male sex, T3-4 tumour stage, N2-3 nodal stage, not receiving systemic treatment, and the presence of systemic metastases were associated with a worse OS. Synchronous PM were diagnosed in 2.0% of patients with lung cancer and resulted in a very poor survival.
肺癌的腹膜转移（PM）较为罕见，其如何影响肺癌患者的预后尚不清楚。这项基于人群的研究旨在评估肺癌腹膜转移的发病率、相关因素、治疗及预后。研究使用了荷兰癌症登记处的数据。纳入了2008年至2018年间所有诊断为肺癌的患者。进行逻辑回归分析以确定与腹膜转移存在相关的因素。进行Cox回归分析以确定与腹膜转移患者总生存期（OS）相关的因素。2008年至2018年间，129,651例患者被诊断为肺癌，其中2533例（2.0%）患者被诊断为腹膜转移。腹膜转移的欧洲标准化率从2008年的0.6显著增加到2018年的1.4（p < 0.001）。年龄在50至74岁之间、肿瘤分期为T3 - 4、淋巴结分期为N2 - 3、肿瘤形态为小细胞肺癌或腺癌以及存在全身转移与腹膜转移的存在相关。腹膜转移患者的中位总生存期为2.5个月。年龄较大、男性、肿瘤分期为T3 - 4、淋巴结分期为N2 - 3、未接受全身治疗以及存在全身转移与较差的总生存期相关。2.0%的肺癌患者被诊断为同时性腹膜转移，其生存情况非常差。
