Department of Neurosurgery and Spine Surgery, University Hospital Essen, Essen, Germany.
Institute for Medical Informatics, Biometry and Epidemiology, University Hospital of Essen, Essen, Germany.
Eur J Neurol. 2021 Jun;28(6):2000-2005. doi: 10.1111/ene.14833. Epub 2021 Apr 3.
To determine the prevalence of cardiovascular comorbidities and allergic diseases in patients with cavernous malformations of the central nervous system compared to the normal population.
Clinical and magnetic resonance imaging data of 1352 patients with cerebral cavernous malformations (CCM) from an observational, cross-sectional, single-institutional study were analyzed and compared to an age-and-gender stratified and matched sample from a population-based, epidemiological study assessing cardiovascular risk factors in the local normal population of the same area (RECALL study).
Of 1352 patients, 810 (60%) were female. Mean age was 40.4 ± 16 years. 221 patients (16%) suffered from familial disease. Presence of cardiovascular risk factors and intake of certain drugs in the overall cohort was mostly equal to the normal population reference sample (n = 786). The prevalence of allergic diseases was found to be significantly higher in all CCM patients compared to the normal population (30% vs. 20%, odds ratio [OR] 1.35 [1.12-1.63]) and in sporadic CCM cases compared to the normal population and familial cases (32% vs. 20% (OR 1.46 [1.19-1.78], p = 0.0001) and 22% vs. 20%, respectively).
We present novel data on CCM using a large single-institution and population-based setup. The study elaborates disease characteristics of CCM patients in detail. For the first time, evidence for an unexplained high prevalence of allergic diseases in this patient population is described (differing between sporadic and familial cases), supporting the hypothesis that immune response is involved in the pathogenesis of CCM.
为了确定与正常人群相比，中枢神经系统海绵状血管畸形患者的心血管合并症和过敏性疾病的患病率。
对一项观察性、横断面、单机构研究中 1352 例脑海绵状血管畸形（CCM）患者的临床和磁共振成像数据进行了分析，并与一项评估同一地区人群心血管危险因素的基于人群、流行病学研究（RECALL 研究）中年龄和性别分层且匹配的样本进行了比较。
在 1352 例患者中，810 例（60%）为女性，平均年龄为 40.4 ± 16 岁，221 例（16%）患有家族性疾病。在整个队列中，心血管危险因素的存在和某些药物的使用与正常人群参考样本基本一致（n=786）。与正常人群相比，所有 CCM 患者的过敏性疾病患病率均明显升高（30%比 20%，优势比[OR]1.35[1.12-1.63]），散发性 CCM 病例与正常人群和家族性病例相比也是如此（32%比 20%，OR 1.46[1.19-1.78]，p=0.0001；22%比 20%）。
我们使用大型单机构和基于人群的设置提供了有关 CCM 的新数据，详细阐述了 CCM 患者的疾病特征。首次描述了该患者群体中未明原因的过敏性疾病高发（散发性和家族性病例之间存在差异），支持免疫反应参与 CCM 发病机制的假说。
