Department of Orthopaedic Surgery, University of Rome "Tor Vergata", Italy.
J Biol Regul Homeost Agents. 2020 Sep-Oct;34(5 Suppl. 1):63-68. IORS Special Issue on Orthopedics.
C-reactive protein (CRP) and Erythrocyte sedimentation rate (ESR) are the two most commonly serum biomarkers for the diagnosis of periprosthetic joint infections (PJI). We monitored CRP and ESR in 60 patients affected by osteoarthritis who underwent primary total hip or knee arthroplasty to verify their utility for an early diagnosis of periprosthetic hip and knee infections. In all but two patients, both CRP and ESR increased rapidly after surgery, reaching a peak value around the 3rd day postoperatively; CRP decreased rapidly in 20 days, reaching normal value one month after surgery, while ESR decreased slowly, reaching the normal value after three months. In two patients, CRP and ESR were still elevated six months after the surgical procedure and in both cases a diagnosis of PJI was made. Our study confirms that postoperative screening of CRP and ESR values are very useful in making an early diagnosis of this serious complication.
C-反应蛋白（CRP）和红细胞沉降率（ESR）是诊断人工关节周围感染（PJI）的两种最常用的血清生物标志物。我们监测了 60 例接受初次全髋关节或全膝关节置换术的骨关节炎患者的 CRP 和 ESR，以验证它们在早期诊断人工髋关节和膝关节感染方面的效用。除了两名患者外，所有患者的 CRP 和 ESR 在手术后均迅速升高，在术后第 3 天达到峰值；CRP 在 20 天内迅速下降，在手术后一个月恢复正常，而 ESR 下降缓慢，在三个月后恢复正常。在两名患者中，手术后六个月 CRP 和 ESR 仍升高，在这两种情况下均诊断为 PJI。我们的研究证实，术后 CRP 和 ESR 值的筛查对于早期诊断这种严重并发症非常有用。
