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左侧开胸术与全胸骨切开术在离心式耐用型左心室辅助装置植入中的比较:LVAD 后和心脏移植后的 1 年结果比较。

Left thoracotomy vs full sternotomy for centrifugal durable LVAD implantation: 1-year outcome comparison post-LVAD and post-heart transplantation.

机构信息

Tufts University School of Medicine, 145 Harrison Ave., Boston, MA, 02111, USA.

Division of Cardiac Surgery, Tufts Medical Center, 800 Washington St., South Building, 6th Floor, Boston, MA, 02111, USA.

出版信息

J Artif Organs. 2021 Sep;24(3):312-319. doi: 10.1007/s10047-021-01250-y. Epub 2021 Mar 19.

Abstract

Left ventricular assist device (LVAD) implantations have traditionally been approached through a full median sternotomy (FS). Recently, a minimally invasive left thoracotomy (LT) approach has been popularized. This study sought to compare the outcomes of FS and LT patients post-primary LVAD implantation and post-subsequent heart transplant (HT). This was a single-center retrospective study. 83 patients who underwent primary centrifugal durable LVAD implantation from January 2014 to June 2018 were included (FS, n = 41; LT, n = 42). 41 patients had a subsequent HT (FS, n = 19; LT, n = 22). Pre-operative patient demographics, intraoperative variables, post-operative 1-year survival, length of hospital stay, complications, and outcomes for LVAD implantation and following HT were analyzed. Intraoperative data showed that the LT group had a 23.4% longer mean LVAD implant surgical time (p < 0.01). One-year post-LVAD survival was similar between the two groups (p = 0.05). Complication rates, with the exception of the rate of hemorrhagic stroke (p = 0.04) post-LVAD implant were similar. One-year survival post-HT was similar between groups (p = 0.35). Complication rates and mean length of hospital stay were also similar (p = 1.0) post-HT. Our study demonstrated that LT approach does not negatively affect post-LVAD implantation or post-HT outcomes. Further, larger studies may determine more detailed effects of LT approach.

摘要

左心室辅助装置 (LVAD) 植入术传统上采用经胸骨正中切开术 (FS)。最近,微创左开胸术 (LT) 已得到普及。本研究旨在比较 FS 和 LT 患者在初次 LVAD 植入术后和随后进行心脏移植 (HT) 后的结局。这是一项单中心回顾性研究。纳入 2014 年 1 月至 2018 年 6 月期间接受初次离心式耐用型 LVAD 植入术的 83 例患者 (FS 组 41 例,LT 组 42 例)。41 例患者随后接受 HT (FS 组 19 例,LT 组 22 例)。分析了术前患者人口统计学资料、术中变量、术后 1 年生存率、住院时间、并发症以及 LVAD 植入术和随后 HT 的结果。术中数据显示,LT 组的 LVAD 植入手术时间平均长 23.4% (p<0.01)。两组术后 1 年生存率相似 (p=0.05)。除 LVAD 植入术后出血性卒中发生率外 (p=0.04),两组并发症发生率相似。两组术后 1 年 HT 生存率相似 (p=0.35)。HT 后并发症发生率和平均住院时间也相似 (p=1.0)。本研究表明,LT 方法不会对 LVAD 植入术后或 HT 后结局产生负面影响。进一步的大样本研究可能会确定 LT 方法的更详细影响。

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