母乳抗体的多效性作用。
The multifaceted roles of breast milk antibodies.
机构信息
Ragon Institute of MGH, MIT, and Harvard, Cambridge, MA, USA; PhD Program in Virology, Division of Medical Sciences, Harvard University, Boston, MA, USA.
Ragon Institute of MGH, MIT, and Harvard, Cambridge, MA, USA.
出版信息
Cell. 2021 Mar 18;184(6):1486-1499. doi: 10.1016/j.cell.2021.02.031.
Neonates are born with an immature immune system and rely on the transfer of immunity from their mothers. Maternal antibodies are transferred via the placenta and breast milk. Although the role of placentally transferred immunoglobulin G (IgG) is established, less is known about the selection of antibodies transferred via breast milk and the mechanisms by which they provide protection against neonatal disease. Evidence suggests that breast milk antibodies play multifaceted roles, preventing infection and supporting the selection of commensals and tolerizing immunity during infancy. Here, we discuss emerging data related to the importance of breast milk antibodies in neonatal immunity and development.
新生儿出生时免疫系统尚未发育成熟，依赖于从母亲那里获得免疫力。母体抗体通过胎盘和母乳传递。尽管胎盘传递的免疫球蛋白 G（IgG）的作用已得到确立，但对于通过母乳传递的抗体的选择以及它们提供针对新生儿疾病保护的机制了解较少。有证据表明，母乳抗体发挥多方面的作用，可预防感染，并在婴儿期支持共生菌的选择和耐受免疫。在这里，我们讨论了与母乳抗体在新生儿免疫和发育中的重要性相关的新数据。
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