Department of Physical Therapy and Assistive Technology, School of Biomedical Science and Engineering, National Yang Ming Chiao Tung University, Taipei, Taiwan.
Institute of Sports Sciences, University of Taipei, Taipei, Taiwan.
Arch Gerontol Geriatr. 2021 Jul-Aug;95:104384. doi: 10.1016/j.archger.2021.104384. Epub 2021 Feb 26.
Some patients with type 2 diabetes mellitus (T2DM) experience decreased mobility associated with lower relative muscle strength (normalized with muscle mass). This study aimed to identify factors predicting relative muscle strength of patients with T2DM assessed at regular clinical visits.
A total of 144 T2DM patients underwent fasting blood drawing (determining white blood cell count [WBC], diabetic kidney disease [DKD], and glycated hemoglobin [HbA1c]) and the assessment of body composition, diabetic peripheral neuropathy (DPN), activity level, and muscle strength (grip, knee extensor, and ankle plantar flexor strength). One-way ANOVA and multiple regression models were used to identify factors associated with the relative muscle strength.
Our data showed that age, diabetes duration, fat percentage, WBC, DPN, and DKD were negatively associated with the relative muscle strength. Specifically, a greater WBC was associated with lower relative muscle strength of both distal and proximal muscle groups of extremities after the adjustment of other associated factors. DPN was associated with lower relative strength of the distal muscle groups of extremities.
WBC may be used as a marker of inflammation, and greater count, even within the normal range, is negatively associated with the relative muscle strength in patients with T2DM.
一些 2 型糖尿病（T2DM）患者由于相对肌肉力量下降（用肌肉质量标准化）而活动能力下降。本研究旨在确定在常规临床就诊时评估 T2DM 患者相对肌肉力量的预测因素。
共 144 名 T2DM 患者接受空腹采血（测定白细胞计数[WBC]、糖尿病肾脏疾病[DKD]和糖化血红蛋白[HbA1c]）和身体成分、糖尿病周围神经病变（DPN）、活动水平和肌肉力量（握力、膝关节伸肌和踝关节跖屈肌力量）评估。使用单因素方差分析和多元回归模型来确定与相对肌肉力量相关的因素。
我们的数据显示，年龄、糖尿病病程、体脂百分比、WBC、DPN 和 DKD 与相对肌肉力量呈负相关。具体而言，在调整其他相关因素后，更大的 WBC 与四肢远端和近端肌肉群的相对肌肉力量降低有关。DPN 与四肢远端肌肉群的相对力量降低有关。
WBC 可作为炎症的标志物，即使在正常范围内，计数较高也与 T2DM 患者的相对肌肉力量呈负相关。
