Department of Emergency Medicine, Ege University, 35100 Izmir, Turkey.
Am J Emerg Med. 2021 Aug;46:102-106. doi: 10.1016/j.ajem.2021.02.057. Epub 2021 Mar 3.
Fever is one of the frequent reasons for admission to the emergency department. Studies comparing oral forms of non-steroidal anti-inflammatory drugs (NSAIDs) and paracetamol with intravenous (IV) forms for fever are common in the literature. Our study is the first emergency department study comparing IV forms of ibuprofen and paracetamol in the treatment of febrile patients.
A randomized, double-blind study was conducted in a tertiary university emergency department for a six-month period. Patients aged 18-65 years who had a fever of ≥38.0 °C were included. Patients were administered 400 mg of IV ibuprofen and 1000 mg of IV paracetamol. The primary aim of the study was to determine whether there was a difference in the effect of the two drugs on fever. The secondary aim was to investigate whether there was a difference in terms of numeric rating scale (NRS) measurements and the need for additional antipyretic therapy.
A total of 200 people, 100 of whom were female, were included in the study. The mean age was 30.77 ± 10.61 years. The mean initial temperature for ibuprofen and paracetamol was 38.79 ± 0.470 °C and 38.70 ± 0.520 °C, respectively, with no difference noted between the groups (p = 0.380). It was found that both drugs significantly provided fever control in the first 30 min (p < 0.001), with no difference between them in terms of fever reduction (p = 0.980). Both drugs significantly improved in accompanying symptoms, although both drugs did not show superiority to each other (p = 0.0226). When evaluated in terms of a need for rescue medication, no significant difference was found between the two drugs (p = 0.404). No side effects were encountered during the study.
In adult age group patients admitted to the emergency department with high fever, the IV forms of 1000 mg paracetamol and 400 mg ibuprofen effectively and equally reduce complaints, such as fever and accompanying pain. They can be effectively used as each other's rescue medicine and as an alternative to each other in patients with comorbid diseases.
发热是急诊科就诊的常见原因之一。比较口服非甾体抗炎药（NSAIDs）和对乙酰氨基酚与静脉（IV）形式用于发热的研究在文献中很常见。我们的研究是首次比较静脉用布洛芬和对乙酰氨基酚治疗发热患者的急诊科研究。
在一家三级大学急诊科进行了一项为期六个月的随机、双盲研究。纳入年龄在 18-65 岁之间、发热≥38.0°C 的患者。患者给予 400mg IV 布洛芬和 1000mg IV 对乙酰氨基酚。研究的主要目的是确定两种药物对发热的疗效是否有差异。次要目的是研究数字评分量表（NRS）测量值和是否需要额外退热治疗方面是否有差异。
共有 200 人，其中 100 人为女性，纳入研究。平均年龄为 30.77±10.61 岁。布洛芬和对乙酰氨基酚的初始平均温度分别为 38.79±0.470°C 和 38.70±0.520°C，两组之间无差异（p=0.380）。结果发现，两种药物在 30 分钟内均能显著控制发热（p<0.001），退热效果无差异（p=0.980）。两种药物均能显著改善伴随症状，尽管两种药物之间没有显示出优越性（p=0.0226）。在评估需要抢救药物方面，两种药物之间无显著差异（p=0.404）。研究过程中未发现不良反应。
在因高热就诊于急诊科的成年患者中，静脉用 1000mg 对乙酰氨基酚和 400mg 布洛芬可有效且同样减轻发热和伴随疼痛等症状。它们可以作为彼此的抢救药物，在患有合并症的患者中可以相互替代。
