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胸主动脉平行支架移植物在径向加载下的行为。

Thoracic aortic parallel stent-graft behaviour when subjected to radial loading.

机构信息

Department of Engineering Science, University of Oxford, Oxford, UK.

Division of Vascular Surgery, Stanford University, Stanford, CA, USA.

出版信息

J Mech Behav Biomed Mater. 2021 Jun;118:104407. doi: 10.1016/j.jmbbm.2021.104407. Epub 2021 Mar 5.

Abstract

To manage complex aortic arch disease using minimally invasive techniques, interventionalists have reported the use of multiple stent-graft devices deployed in a parallel configuration. The structural device-device and device-artery interactions arising during aortic arch parallel endografting, also known as chimney thoracic endovascular aortic repair (ch-TEVAR), is not well understood. Through the use of a radial force testing system we sought to characterise both the loading and deformation behaviour of parallel endografts in representative ch-TEVAR configurations. Four commercially available devices (Bentley BeGraft, Gore TAG, Gore Viabahn, and Medtronic Valiant) were subjected to uniform radial load individually, and in six combinations, to quantify loading profiles. Image data collected during testing were analysed to evaluate mechanical deformations in terms of gutters, chimney and main endograft compression, as well as graft infolding. Parallel endografting was found to increase radial loads when compared to standard TEVAR. Chronic outward force during ch-TEVAR was dependent on main endograft manufacturer, with TAG combinations leading to consistently higher loads than Valiant, but independent of chimney graft type. Endograft deformations were dependent on chimney graft type, with Viabahn combinations presenting with lower gutter areas and increased lumen compression than BeGraft. Chimney graft deformations were also influenced by deployment arrangement in the case of double ch-TEVAR. This study emphasizes the significant variability in both radial loads and mechanical deformations between clinically relevant ch-TEVAR configurations.

摘要

为了使用微创技术来治疗复杂的主动脉弓疾病,介入医生报告了使用多个支架移植物以平行配置部署的方法。在主动脉弓平行腔内修复术(ch-TEVAR)中,支架-支架和支架-动脉之间的结构相互作用尚未得到很好的理解。通过使用径向力测试系统,我们试图描述在代表性的 ch-TEVAR 配置中平行支架的加载和变形行为。将四种市售的器械(Bentley BeGraft、Gore TAG、Gore Viabahn 和 Medtronic Valiant)单独和以六种组合方式进行均匀的径向加载,以量化加载曲线。分析测试过程中收集的图像数据,以评估肠腔、烟囱和主要支架压缩以及移植物内陷等方面的机械变形。与标准 TEVAR 相比,平行支架植入会增加径向负载。ch-TEVAR 过程中的慢性向外力取决于主要支架制造商,与 Valiant 相比,TAG 组合始终导致更高的负载,但与烟囱移植物类型无关。支架变形取决于烟囱移植物类型,与 BeGraft 相比,Viabahn 组合的肠腔面积更小,管腔压缩更大。在双 ch-TEVAR 的情况下,烟囱移植物的变形也受到部署排列的影响。本研究强调了在临床相关的 ch-TEVAR 配置中,径向负载和机械变形之间存在显著的可变性。

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