Division of Rheumatology, Department of Internal Medicine, Catholic University of Daegu School of Medicine, 33, Duryugongwon-ro 17-gil, Nam-gu, Daegu, 42472, Republic of Korea.
Adv Rheumatol. 2021 Mar 19;61(1):19. doi: 10.1186/s42358-021-00177-5.
This study identified whether Functional Index for Hand Osteoarthritis (FIHOA) is associated with pain, hand muscle strength, health-related quality of life, and radiographic severity in hand osteoarthritis (OA).
We consecutively recruited 95 patients with hand OA. The FIHOA was used to assess questionnaire-based physical function in hand OA. Health-related quality of life was evaluated using EuroQol-5 dimension (EQ-5D). Radiographic changes of hand joints were measured by Kellgren-Lawrence (K-L) grade, which was determined based on total radiographic severity score and number of affected joints. Other measures included patient's visual analogue scale (VAS) score for pain and performance-based function indexes such as grip and pinch strength. Statistical analysis was performed using Mann-Whitney U test, Spearman's correlation analysis, and multivariate logistic regression analysis.
FIHOA score was negatively associated with grip and pinch hand strength and EQ-5D and positively correlated to VAS pain (p < 0.05 for all). There were significant differences of grip and pinch strength, VAS pain, EQ-5D index, and EQ-VAS between two FIHOA groups (≤ 4 vs. > 4) (p < 0.05 for all). Multivariate logistic regression analysis showed that higher FIHOA score (FIHOA > 4) was related with increased VAS pain and with lower EQ-5D index (p = 0.008 and p = 0.013, respectively). There was no association between FIHOA score and measures of total radiographic severity score and number of affected joints.
This study observes that FIHOA score is associated with patient-reported VAS pain, hand muscle strength indexes, and EQ-5D but not radiographic severity in hand OA.
本研究旨在确定手部骨关节炎（OA）患者的手部关节炎功能指数（FIHOA）与疼痛、手部肌肉力量、健康相关生活质量和手部 OA 放射学严重程度之间的相关性。
我们连续招募了 95 例手部 OA 患者。FIHOA 用于评估手部 OA 患者的基于问卷的身体功能。健康相关生活质量采用 EuroQol-5 维度（EQ-5D）进行评估。手部关节的放射学变化通过 Kellgren-Lawrence（K-L）分级进行测量，该分级基于总放射学严重程度评分和受累关节数确定。其他测量指标包括患者的视觉模拟量表（VAS）疼痛评分和基于表现的功能指标，如握力和捏力。统计分析采用 Mann-Whitney U 检验、Spearman 相关分析和多变量逻辑回归分析。
FIHOA 评分与握力和捏力以及 EQ-5D 呈负相关，与 VAS 疼痛呈正相关（所有 p 值均<0.05）。在 FIHOA 评分≤4 分和>4 分两组之间，握力和捏力、VAS 疼痛、EQ-5D 指数和 EQ-VAS 均有显著差异（所有 p 值均<0.05）。多变量逻辑回归分析显示，FIHOA 评分较高（FIHOA>4）与 VAS 疼痛增加和 EQ-5D 指数降低相关（p=0.008 和 p=0.013）。FIHOA 评分与总放射学严重程度评分和受累关节数之间无相关性。
本研究观察到 FIHOA 评分与患者报告的 VAS 疼痛、手部肌肉力量指标和 EQ-5D 相关，但与手部 OA 的放射学严重程度无关。
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