Nagoshi C T, Dixon L K, Johnson R C, Yuen S H
Institute for Behavioral Genetics, University of Colorado, Boulder 80309-0447.
J Stud Alcohol. 1988 May;49(3):261-7. doi: 10.15288/jsa.1988.49.261.
Multivariate path analysis was used to examine the etiologies of variation and covariation of flushing after alcohol use in nuclear families of Korean, Taiwanese, Japanese and Caucasian ancestries. Phenotypic variances and covariances were partitioned into familial (additive genetic and common family environment) and environmental components. Although alcohol consumption and flushing varied greatly among the different groups, familialities, estimated from components of mother, father and at least one child, were remarkably similar. The familialities for flushing were 0.48 for Japanese, 0.56 for Koreans and 0.35 for Taiwanese; flushing is infrequent in Caucasians and thus was not analyzed. Familialities were lower for consumption, but like flushing, were consistent across ethnic groups (Japanese, 0.27; Koreans, 0.24; Taiwanese, 0.15; Caucasians, 0.28). The genetic correlation between flushing and alcohol consumption was high. Thus, to the extent that flushing influences alcohol consumption, the covariance is most likely genetic.
多变量路径分析用于研究具有韩国、台湾、日本和高加索血统的核心家庭中饮酒后脸红的变异和协变的病因。表型方差和协方差被划分为家族性（加性遗传和共同家庭环境）和环境成分。尽管不同群体之间的饮酒量和脸红情况差异很大，但根据母亲、父亲和至少一个孩子的成分估计的家族性却非常相似。日本人脸红的家族性为0.48，韩国人为0.56，台湾人为0.35；高加索人很少脸红，因此未进行分析。饮酒的家族性较低，但与脸红一样，在不同种族群体中是一致的（日本人，0.27；韩国人，0.24；台湾人，0.15；高加索人，0.28）。脸红与饮酒之间的遗传相关性很高。因此，就脸红影响饮酒的程度而言，协方差很可能是遗传的。
