Department of Neurosurgery, Division of Pediatric Neurosurgery, Acıbadem University School of Medicine, Istanbul, Turkey.
Department of Pathology, Acıbadem University School of Medicine, Istanbul, Turkey.
Childs Nerv Syst. 2021 Dec;37(12):3933-3937. doi: 10.1007/s00381-021-05119-6. Epub 2021 Mar 19.
A new entity of gliomas, named "diffuse midline glioma (DMG), H3K27M mutant (grade IV)," which represents a specific molecular profile, was introduced to the World Health Organization (WHO) classification 2016 of central nervous system tumors. Many midline localizations have been described for this glioma, and mainly the hypothalamus, pons, thalamus, and spinal cord are sites of predilection in pediatric and young adult patients. We report the case of spinal intramedullary DMG, H3K27M mutant (WHO grade IV), that showed an unusual presentation with multiple vertebral metastases.
一种新的神经胶质瘤实体，名为“弥漫性中线胶质瘤（DMG），H3K27M 突变型（IV 级）”，代表了一种特定的分子谱，被引入 2016 年世界卫生组织（WHO）中枢神经系统肿瘤分类。这种神经胶质瘤有许多中线定位，主要是下丘脑、脑桥、丘脑和脊髓，是儿科和年轻成年患者的好发部位。我们报告了一例脊髓髓内 DMG，H3K27M 突变型（WHO 分级 IV），其表现为一种不常见的多椎体转移形式。
