Leibniz Institute for Neurobiology, Brenneckestrasse 6, 39118, Magdeburg, Germany.
Biol Cybern. 2021 Apr;115(2):177-190. doi: 10.1007/s00422-021-00868-8. Epub 2021 Mar 19.
The inhomogeneous Poisson point process is a common model for time series of discrete, stochastic events. When an event from a point process is detected, it may trigger a random dead time in the detector, during which subsequent events will fail to be detected. It can be difficult or impossible to obtain a closed-form expression for the distribution of intervals between detections, even when the rate function (often referred to as the intensity function) and the dead-time distribution are given. Here, a method is presented to numerically compute the interval distribution expected for any arbitrary inhomogeneous Poisson point process modified by dead times drawn from any arbitrary distribution. In neuroscience, such a point process is used to model trains of neuronal spikes triggered by the detection of excitatory events while the neuron is not refractory. The assumptions of the method are that the process is observed over a finite observation window and that the detector is not in a dead state at the start of the observation window. Simulations are used to verify the method for several example point processes. The method should be useful for modeling and understanding the relationships between the rate functions and interval distributions of the event and detection processes, and how these relationships depend on the dead-time distribution.
非均匀泊松点过程是离散随机事件时间序列的常用模型。当点过程中的事件被检测到时,它可能会触发探测器中的随机死区时间,在此期间后续事件将无法被检测到。即使给出了率函数(通常称为强度函数)和死区时间分布,也很难或不可能获得检测间隔分布的封闭形式表达式。本文提出了一种方法,可以针对任何通过从任意分布中抽取的死区时间修改的非均匀泊松点过程,数值计算出所期望的间隔分布。在神经科学中,这种点过程用于模拟神经元在不应期时因检测到兴奋性事件而引发的神经元尖峰序列。该方法的假设是,过程是在有限的观测窗口中观测的,并且在观测窗口开始时探测器不在死区状态。使用模拟来验证几种示例点过程的方法。该方法应该有助于对事件和检测过程的率函数和间隔分布之间的关系以及这些关系如何取决于死区时间分布进行建模和理解。